Amino Acids
Amino Acids
Enzo Life Sciences L-Cycloserine (100mg). CAS: 339-72-0
Ketosphinganine synthase inhibitor. Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor. Alternative name: S(-)-4-Amino-3-isoxazolidinone. Formula: C3H6N2O2. MW: 102.1. MI: 14: 2751. Purity: ≥98% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in water. Use/Stability: Unstable in neutral or acidic solutions. Long Term Storage: -20°C. Handling: Hygroscopic.
Enzo Life Sciences N-Acetyl-S-farnesyl-L-cysteine (5mg). CAS: 135304-07-3
Members of the Ras superfamily of G proteins, γ-subunits of heterotrimeric G proteins and the α-subunit of cGMP phosphodiesterase from retinal rods are all carboxyl methylated at carboxy-terminal S-farnesylcysteine residues. AFC specifically inhibits the S-farnesylcysteine methyl transferase (Km=20 µM) in cell free extracts and in whole cells. It inhibits carboxyl methylation of p21ras platelet Rap15 and the γ-subunit of transducin. It blocks receptor-mediated signal transduction in platelets and neutrophils not by inhibiting the methyltransferase, but possibly by inhibiting capacitative Ca2+ entry. Alternative name: AFC. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml), methanol or 100% ethanol (25mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences N-Arachidonylglycine (5mg). CAS: 179113-91-8
Endogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki>10µM), TRPV1 (EC50>10µM) and anandamide uptake (IC50>50µM), but inhibits fatty acid amide hydrolase (FAAH) (IC50=8.5µM-50µM, depending on cell type and species). Displays anti-inflammatory and analgesic activity. Identified as an insulin secretagogue in a primary β-cell-based functional assay. Represents a new class of "lipoamino acids". Purity: ≥98% (TLC). Solubility: Soluble in DMSO or 100% ethanol. 2mg/ml soluble in PBS (pH 7.2). Long Term Storage: -20°C.
Enzo Life Sciences N-Acetyl-S-farnesyl-L-cysteine (25mg). CAS: 135304-07-3
Members of the Ras superfamily of G proteins, γ-subunits of heterotrimeric G proteins and the α-subunit of cGMP phosphodiesterase from retinal rods are all carboxyl methylated at carboxy-terminal S-farnesylcysteine residues. AFC specifically inhibits the S-farnesylcysteine methyl transferase (Km=20 µM) in cell free extracts and in whole cells. It inhibits carboxyl methylation of p21ras platelet Rap15 and the γ-subunit of transducin. It blocks receptor-mediated signal transduction in platelets and neutrophils not by inhibiting the methyltransferase, but possibly by inhibiting capacitative Ca2+ entry. Alternative name: AFC. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml), methanol or 100% ethanol (25mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences N-Methyl-D-aspartic acid (50mg). CAS: 6384-92-5
Selective ionotropic NMDA receptor agonist. Excitatory amino acid. Alternative name: NMDA. Formula: C5H9NO4. MW: 147.1. Purity: ≥98% (TLC). Solubility: Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol. Long Term Storage: Ambient.
Enzo Life Sciences N-Acetyl-Asp-Glu-OH (50mg). CAS: 3106-85-2
Glutamate receptor ligand. Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective. Alternative name: alpha NAAG, Spaglumic acid. Formula: C11H16N2O8. MW: 304.3. Purity: ≥98% (TLC). Appearance: White to off-white powder. Solubility: Soluble in water and methanol (50mg/ml). Long Term Storage: +4°C.
Enzo Life Sciences L-Theanine (25g). CAS: 3081-61-6
Amino acid analog of glutamine, uniquely found in green tea. Increases brain serotonin, dopamine and GABA levels and binds to AMPA, kainate and NMDA receptors. Has been shown to exert neuroprotective effects in animal models possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. Behavioural studies with rats suggest L-Theanine to positiveley affect learning and memory processes. Promotes self-renewal of human embryonic stem cells. Alternative name: Ngamma-Ethyl-L-glutamine, L-Glutamic acid gamma-(ethylamide). Formula: C7H14N2O3. MW: 174.20. Purity: ≥98% (Titration). Appearance: White to off-white solid. Solubility: Soluble in water (50mg/ml). Long Term Storage: +4°C. Handling: Protect from moisture.
Enzo Life Sciences Suc-Leu-Tyr-AMC (5mg). CAS: 94367-20-1
Substrate for porcine calpain I and II. Also cleaved by papain and E. coli protease Ti. Ex.: 340-360nm, Em.: 440-460nm. This substrate is useful for inhibitor screening and kinetic analysis. Alternative name: Suc-LY-AMC. Formula: C29H33N3O8. MW: 551.6. Purity: ≥95%. Solubility: Soluble in 80% acetic acid, DMSO or methanol. Long Term Storage: -20°C.
Enzo Life Sciences S-Farnesyl-L-cysteine methyl ester (25mg). CAS: 125741-64-2
Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25 mg/ml) and ethanol (25 mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences N-Acetyl-S-geranylgeranyl-L-cysteine (25mg). CAS: 139332-94-8
AGGC specifically blocks methyl esterification of geranylgeranylated proteins such as Rab proteins. AGGC blocks receptor-mediated signal transduction in human neutrophils (IC50=4 µM). Induces insulin release from HIT-T15 cells by mimicking the action of Rab3A and inhibits β2-integrin-induced actin polymerization (IC50~45 nM) in neutrophils. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences Farnesyl thiotriazole (10mg). CAS: 156604-45-4
A structurally unique activator of PKC in whole cells or in purified enzyme preparations (Kd=2.5 µM) which is equipotent with dioleoylglycerol. Since it does not possess hydrolyzable esters of fatty acids, it represents a stable, persistent PKC activator. Alternative name: FTT. Purity: ≥98% (TLC). Solubility: Soluble in DMSO or 100% ethanol. Long Term Storage: -20°C.
Enzo Life Sciences H1-7 (1mg). CAS: 65189-70-0
This sequence, RRKASGP, is derived from calf thymus histone H1 containing Ser38. Peptide is phosphorylated by protein kinase A. Alternative name: Histone H1 phosphorylation site, PKA substrate, Arg-Arg-Lys-Ala-Ser-Gly-Pro, RRKASGP. Purity: ≥97%. Long Term Storage: -20°C.
Enzo Life Sciences TPCK (1g). CAS: 402-71-1
Irreversible inhibitor of chymotrypsin-like serine proteases such as granzyme D. Inhibits LPS-induced expression of COX-2 in macrophages. Inhibits γ-irradiation-induced apoptosis in myeloid leukemic cells. Alternative name: N alpha-Tosyl-Phe-chloromethylketone. Purity: ≥98%. Long Term Storage: -20°C.
Enzo Life Sciences L-Ergothioneine (50mg). CAS: 497-30-3
Naturally occuring ubiquitous antioxidant which is found in many cells at concentrations up to 2 mM. Peroxynitrate ONOO- scavenger. Protects human neuronal hybridoma cell line (N-18-RE-105) from ONOO--induced oxidative damage. Purity: ≥98% (TLC). Solubility: Soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences Z-Pro-Nle-Asp-al (100 µg)
Highly specific aldehyde based inhibitor for the caspase-like peptidic activity of the 20S proteasome. Purity: ≥95% (HPLC). Formulation: Lyophilized. Solubility: Soluble in water (1mg/ml). Long Term Storage: -20°C.