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Enzo Life Sciences N-Acetyl-S-farnesyl-L-cysteine (5mg). CAS: 135304-07-3
SDP

Supplier:  Enzo Life Sciences BMLG2000005

Encompass_Preferred

Members of the Ras superfamily of G proteins, γ-subunits of heterotrimeric G proteins and the α-subunit of cGMP phosphodiesterase from retinal rods are all carboxyl methylated at carboxy-terminal S-farnesylcysteine residues. AFC specifically inhibits the S-farnesylcysteine methyl transferase (Km=20 µM) in cell free extracts and in whole cells. It inhibits carboxyl methylation of p21ras platelet Rap15 and the γ-subunit of transducin. It blocks receptor-mediated signal transduction in platelets and neutrophils not by inhibiting the methyltransferase, but possibly by inhibiting capacitative Ca2+ entry. Alternative name: AFC. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml), methanol or 100% ethanol (25mg/ml). Long Term Storage: -20°C.

Catalog No. 50-201-0849


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