Bioactive Small Molecules
Bioactive Small Molecules
Enzo Life Sciences Corticosterone (50mg). CAS: 50-22-6
Alternative name: (11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein's Substance H. Purity: ≥98% (HPLC). Solubility: Soluble in 100% ethanol (50mg/ml) or dioxane (20mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences 20-Hydroxyecdysone (5mg). CAS: 5289-74-7
Most widely occurring ecdysteroid in both plant and animal species. Controls cell death during metamorphosis of Drosophila melanogaster. Alternative name: beta-Ecdysone, 2beta,3beta,14alpha,20R,22R,25-Hexahydroxy-5beta-cholest-7-en-6-one, Ecdysterone. Purity: ≥95% HPLC. Solubility: Soluble in water, 100% ethanol, methanol, DMSO and acetic acid. Long Term Storage: -20°C.
Enzo Life Sciences Carboplatin (100mg). CAS: 41575-94-4
An analog of cisplatin (ALX-400-040). Antitumor agent. Alternative name: cis-Diammine [1,1-cyclobutanedicarboxylato] platinum (II). Purity: ≥98% (HPLC). Solubility: Soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences Amidepsine A (2.5mg). CAS: 169181-28-6
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2µM) and Raji cells (IC50=15.5µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders. Purity: ≥95% (HPLC). Appearance: Pale white to pale yellow powder. Solubility: Soluble in methanol, ethyl acetate or benzene; insoluble in water or hexane. Long Term Storage: -20°C.
Enzo Life Sciences Carboplatin (25mg). CAS: 41575-94-4
An analog of cisplatin (ALX-400-040). Antitumor agent. Alternative name: cis-Diammine [1,1-cyclobutanedicarboxylato] platinum (II). Purity: ≥98% (HPLC). Solubility: Soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences Teniposide (25mg). CAS: 29767-20-2
Glycoside-derivative of podophyllotoxin. Has cytostatic effect. Inhibits topoisomerase II. Induces apoptosis. Alternative name: (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 4'-Demethylepipodophyllotoxin-beta-D-thenylidine glucoside. Purity: ≥97% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in acetone or dimethyl formamide; slightly soluble in methanol; insoluble in water. Long Term Storage: -20°C.
Enzo Life Sciences Diacylglycerol Kinase Inhibitor II (R59 949) (25mg). CAS: 120166-69-0
Inhibitor of diacylglycerol kinase in intact cells (IC50=0.12µM) and in isolated membranes (IC50=0.3µM). More potent analog of R59 022 (ALX-430-027). Useful for elucidating roles of protein kinase C (PKC). Alternative name: 3-[2-[4-[bis(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone. Purity: ≥98% (HPLC). Solubility: Soluble in dichloromethane, ethyl acetate, tetrahydro-furan, DMSO (33mg/ml) or dimethyl formamide; almost insoluble in water. Long Term Storage: +4°C.
Enzo Life Sciences PAC-1 (10mg). CAS: 315183-21-2
First molecule to directly activate procaspase-3 to caspase-3 in vitro. Has been shown to induce apoptosis in cancer cells. Alternative name: 4-(Phenylmethyl)[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide-1-piperazineacetic acid. Purity: ≥98% (HPLC (UV)). Solubility: Soluble in acetonitrile, DMSO, dioxane or methanol. Long Term Storage: -20°C.
Enzo Life Sciences 8-Hydroxyguanosine (5mg). CAS: 3868-31-3
Oxidized form of the nucleoside guanosine. Formed in vivo by the free radical oxidation of RNA molecules, with subsequent degradation and cleavage of the nucleic acid. Alternative name: 8-OHG. Purity: ≥98% (HPLC). Solubility: Soluble in conc. NaOH. Once solubilized it can be further diluted and neutralized with water. Long Term Storage: -20°C.
Enzo Life Sciences Trimethylammonio-PTIO. methylsulfate (50mg)
Water soluble nitric oxide (NO) spin trap that is non-cell permeable, allowing study of extracellular NO release. Alternative name: TMA-PTIO . CH3SO4-, 3,3,4,4-Tetramethyl-2-trimethylammoniophenyl-2-imidazoline-3-oxide-1-yloxy methylsulfate. Purity: ≥80% (Assay). Appearance: Dark blue crystalline solid. Solubility: Soluble in water, 100% ethanol or DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Nutlin-3 (5mg). CAS: 548472-68-0
(+/-) -Nutlin-3 is an inhibitor of p53/MDM2 interaction (IC50=0.09µM). Alternative name: (+/-)-4-[4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-piperazin-2-one. Purity: ≥98% (HPLC (UV)). Solubility: Soluble in methanol, 100% ethanol, DMSO, dimethyl formamide or acetonitrile; sparingly soluble in a 1:10 solution of ethanol:PBS, pH 7.2. Long Term Storage: -20°C.
Enzo Life Sciences Zoledronic acid (25mg). CAS: 165800-06-6
Inhibitor of osteoclastic bone resorption. Prevents osteoporosis and skeletal fractures, particularly in patients with multiple myeloma or prostate cancer. Also used to treat hypercalcemia. Inhibition of acid sphingomyelinase (aSMase) with an IC50 5µm. Alternative name: 1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid, CGP 42446. Purity: ≥98% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in 0.1N NaOH. Sparingly soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences Pinacidil . monohydrate (50mg). CAS: 85371-64-8
K+ channel activator. Antihypertensive. Alternative name: (+/-)-N-Cyano-N-4-pyridinyl-N-(1,2,2-trimethylpropyl)guanidine monohydrate. Purity: ≥98% (HPLC). Solubility: Soluble in 100% ethanol (14mg/ml), DMSO (28mg/ml) or dilute aqueous acid; insoluble in water. Long Term Storage: Ambient.
Enzo Life Sciences MPEP . hydrochloride (25mg). CAS: 96206-92-7
Potent and selective antagonist for mGluR5 receptor. Systemically active in vivo. Alternative name: 6-Methyl-2-(phenylethynyl)-pyridine . HCl. Purity: ≥99%. Solubility: Soluble in water, DMSO or methanol. Long Term Storage: +4°C.
Enzo Life Sciences Dimethyl-W84 dibromide (5mg). CAS: 402475-33-6
Very potent allosteric modulator of muscarinic receptors, selective for M2-receptors. Retards the dissociation of the antagonist N-methylscopolamine. Affinity for the free receptor is about 10-fold higher than with W84 (ALX-550-399). pKA=7.08, p(αKA)=6.75, pEC50,diss=6.77. Alternative name: N,N-Bis[3-(1,3-dihydro-5-methyl-1,3-dioxo-2H-isoindol-2-yl)propyl]-N,N,N,N-tetramethyl-1,6-hexanediamminium dibromide. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO, water or aqueous buffer. Long Term Storage: +4°C.