Organoheterocyclic compounds
Organoheterocyclic compounds
![Enzo Life Sciences ET A receptor antagonist [BQ-123]. sodium salt (5mg). CAS: 136553-81-6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/ENZOLOGO.png-250.jpg)
Enzo Life Sciences ET A receptor antagonist [BQ-123]. sodium salt (5mg). CAS: 136553-81-6
Highly potent and selective ETA antagonist. Formula: C31H42N6O7 . Na. MW: 633.7. Purity: ≥96%. Solubility: Soluble in water. Long Term Storage: -20°C. Use/Stability: Stable for at least 3 years after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
Enzo Life Sciences ET A receptor antagonist [BQ-610] (1mg). CAS: 141595-53-1
30-fold more potent ETA antagonist than BQ-123 in pig aortic smooth muscle membrane assay, same activity as BQ-123 when tested on pig cerebellum membrane. Formula: C36H44N6O6. MW: 656.8. Long Term Storage: -20°C.
Enzo Life Sciences Bisindolylmaleimide II (5mg). CAS: 137592-45-1
Formula: C27H26N4O2. MW: 438.5. Purity: ≥97% (HPLC). Appearance: Orange solid. Solubility: Soluble in DMSO or 100% ethanol. Long Term Storage: -20°C. Handling: Protect from light.
Enzo Life Sciences BIX 01294 (2mg). CAS: 935693-62-2
Selective and cell permeable inhibitor of G9a histone methyltransferase. Purity: ≥95% (HPLC). Appearance: White solid. Solubility: Soluble in DMSO (5mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences Bisindolylmaleimide II (1mg). CAS: 137592-45-1
PKC inhibitor. Formula: C27H26N4O2. MW: 438.5. Purity: ≥97% (HPLC). Appearance: Orange solid. Solubility: Soluble in DMSO or 100% ethanol. Long Term Storage: -20°C. Handling: Protect from light.
Enzo Life Sciences Bisindolylmaleimide III (1mg)
PKC inhibitor. Potent and selective inhibitor of protein kinase C (PKC). Formula: C23H20N4O2. MW: 384.4. Purity: ≥98%. Solubility: Soluble in methanol or DMSO. Long Term Storage: -20°C. Handling: Protect from light.
Enzo Life Sciences Palbociclib. isethionate (200mg). CAS: 827022-33-3
Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Alpelisib (free base) (50mg). CAS: 1217486-61-7
Alpelisib is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ Alternative name: BYL719. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Ceritinib (free base) (50mg). CAS: 1032900-25-6
Ceritinib is a selective inhibitor of ALK, a target found in metastatic non-small cell lung cancer. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Wiskostatin (1 mg). CAS: 253449-04-6
A selective, reversible inhibitor of N-WASP (neural Wiskott-Aldrich syndrome protein) that selectively blocks actin filament assembly. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex. Purity: ≥98% (HPLC). Solubility: Soluble in ethanol (10 mg/ml with warming) or DMSO (25 mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences Ginkgolide B (10mg). CAS: 15291-77-7
Most potent member of the ginkgolide family of PAF antagonists. Ginkgolide B accelerates PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Inhibits PAF-induced PMNL chemotaxis (IC50=490 nM). Orally effective against PAF-induced bronchospasm. Alternative name: BN 52021. Purity: ≥90% (HPLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (2mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences Clozapine, (50mg), CAS Number: 5786-21-0
Dopamine receptor and serotonin receptor antagonist. Dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors. Alternative Name: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine. Formula: C18H19ClN4. MW: 326.8. CAS Number: 5786-21-0. MI: 14: 2423. Purity: ≥99% (HPLC). Appearance: Yellow crystalline powder. Solubility: Soluble in DMSO (30mg/ml) or dilute aqueous acid. Long Term Storage: +4°C
Enzo Life Sciences Nadifloxacin (1g). CAS: 124858-35-1
Fluoroquinolone with broad spectrum activity against Gram-negative and Gram-positive bacteria. Inhibits the generation of O2- and OH radicals by neutrophils. Inhibits the production of inflammatory cytokines. Alternative name: 9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid, Jinofloxacin, OPC-7251. Purity: ≥98% (Assay). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Protoporphyrin IX (free acid) (1g). CAS: 553-12-8
Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable. Alternative name: 8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid. Purity: ≥95% (HPLC). Appearance: Purple to dark brown solid. Solubility: Dissolve initially in 0.1M base (Tris base or NaOH), then add water miscible organic solvent (EtOH (10mg/ml), MeOH, DMSO (10mg/ml), DMF) until solution is 50/50 base/solvent. When a clear solution is obtained, it can be diluted into an aqueous medium and titrated or buffered to any pH>7. Use immediately. Long Term Storage: -20°C.
Enzo Life Sciences Zinc(II) Protoporphyrin IX (25mg). CAS: 15442-64-5
Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter. Purity: ≥95% (TLC). Solubility: Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures. Long Term Storage: -20°C.