Benzenoids
Benzenoids
Enzo Life Sciences CAT1H . hydrochloride (250mg)
Cyclic hydroxylamine spin probe for in vivo, intraperitoneal and intravenous injections. Lifetime of more than 4 hours in blood plasma, in cells and tissue. Allows quantitative measurements of extracellular O2•– and quantification of intracellular O2•– in cells and tissue samples and in vivo O2•– detection. Alternative name: 1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl-trimethylammonium chloride . HCl. Appearance: Colorless crystalline solid. Solubility: Soluble in water, methanol or 100% ethanol. Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin 47 (RG-50864) (AG-213) (5mg). CAS: 122520-86-9
A potent inhibitor of EGF receptor kinase activity (IC50‘s:EGFR = 2.4 µM, PDGFR = 3.5 µM, p210bcr-abl=5.9 µM, insulin receptor = 640 µM). Purity: ≥99% (TLC). Solubility: Soluble at 20 mg/ml in 100% ethanol or DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin 1 (20mg). CAS: 2826-26-8
An inactive tyrphostin, which may be used as a negative control. Purity: ≥99%. Solubility: Soluble in 100% ethanol (25mg/ml, warm) or DMSO (25mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences ZM 336372 (25mg). CAS: 208260-29-1
Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells. Alternative name: N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide. Purity: ≥95% (HPLC). Solubility: Soluble in DMSO (200mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences SB-3CT (5mg). CAS: 292605-14-2
Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (at least 30mM) or 100% ethanol. Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin 25 (RG-50875) (5mg). CAS: 118409-58-8
A potent inhibitor of EGF receptor kinase activity (IC50=3 µM). Purity: ≥99%. Solubility: Soluble in 100% ethanol or DMSO. Long Term Storage: Ambient.
Enzo Life Sciences Mycophenolate mofetIL-(100mg). CAS: 128794-94-5
Mycophenolate mofetil (CellCept) is an immunosuppressant prodrug of mycophenolic acid, a fermentation product of Penicillium brevicompactum. Immunosuppression occurs via inhibition of type II inosine-5’-monophosphate dehydrogenase, depleting guanosine preferentially in T and B lymphocytes. In addition, mycophenolic acid displays anti-inflammatory activity by preventing NO production specifically from iNOS and by blocking glycosylation and expression of adhesion molecules and therefore recruitment of lymphocytes and monocytes to sites of inflammation. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml, warm). Long Term Storage: Ambient.
Enzo Life Sciences L-Thiocitrulline . dihydrochloride (50mg). CAS: 212051-53-1
Inhibitor of neuronal (nNOS; NOS I; Ki=60nM) and inducible (iNOS; NOS II) nitric oxide synthase. Formula: C6H13N3O2S . 2HCl. MW: 191.3 . 72.9. Purity: ≥97% (TLC). Appearance: White solid. Solubility: Soluble in water or DMSO. Long Term Storage: +4°C.
Enzo Life Sciences N-Arachidonoyldopamine (25 mg). CAS: 199875-69-9
Endogenous, specific ligand for the CB1 receptor (CB1: Ki=250nM; CB2: Ki=12µM) [1] and TRPV1 [2] (EC50=50nM) found in nervous tissues [3, 4]. Immunosuppressant inhibiting T cell proliferation and phosphorylation of the NF-κB p65 subunit [5]. Potent vasorelaxant [6] and inhibitor of HIV-1 [7]. Alternative name: N-Arachidonoyl-3-hydroxytyramine, NADA, AA-DA. Purity: ≥98% (TLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences SB-366791 (5 mg). CAS: 472981-92-3
A potent and selective vanilloid receptor (TRPV1) antagonist. An effective antagonist of hTRPV1 when stimulated by capsaicin, acid, or noxious heat. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml with warming). Long Term Storage: Ambient.
Enzo Life Sciences Dabrafenib (free base) (100mg). CAS: 1195765-45-7
Dabrafenib is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Dacomitinib (free base) (500mg). CAS: 1110813-31-4
Dacomitinib is a potent, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Idelalisib (free base) (50mg). CAS: 870281-82-6
Idelalisib is a PI3K-δ inhibitor with potential immunomodulating and antineoplastic activities. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Rucaparib phosphate (25mg). CAS: 459868-92-9
Rucaparib is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Rucaparib phosphate (100mg). CAS: 459868-92-9
Rucaparib is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.