Unclassified Organic Compounds
Unclassified Organic Compounds
Enzo Life Sciences Ganglioside GT1b . trisodium salt (bovine brain) (5 mg) CAS: 59247-13-1
Prevents neurotoxicity of glutamate on neuronal cells. Synonyms: GT1b . 3Na (bovine brain), Trisialoganglioside GT1b . 3Na (bovine brain). Formula: C95H162N5O47 . 3Na. MW: 2126.3 . 69.0 (calculated on sphingosine C18:1 and stearic acid).
Enzo Life Sciences Myriocin (5 mg) CAS: 35891-70-4
Palmitoyltransferase inhibitor. Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No. BML-A195). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (Ki=0.28nM), therefore useful as a tool to deplete cells of sphingolipids. Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC50=15nM). Synonyms: ISP-1, Thermozymocidin, 2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid. Formula: C21H39NO6. MW: 401.5.
Enzo Life Sciences PTIO (100mg). CAS: 18390-00-6
Stable nitric oxide (NO) radical scavenger. Alternative name: 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide. Purity: ≥98% (Nonaqueous Titration). Solubility: Soluble in methanol, 100% ethanol or water. Long Term Storage: -20°C.
Enzo Life Sciences Polymyxin B . sulfate (1g). CAS: 1405-20-5
Antibiotic. Inhibitor of protein kinase C (PKC). Breaks the bacterial membrane by incorporating into the phospholipid of the outer membrane and activating phospholipase. Purity: ≥80% (HPLC) (sum of polymyxins B1, B2, B3, B1-I). Solubility: Soluble in water (50mg/ml). Long Term Storage: +4°C.
Enzo Life Sciences Diethyldithiocarbamic acid. sodium salt. trihydrate (high purity) (25g). CAS: 20624-25-3
Nitric oxide (NO) spin-trapping reagent. Thiol and iron chelator. Inhibits induction of macrophage nitric oxide synthase (NOS). Has been shown to be an inhibitor of the nuclear transcription factor κB (NF-κB). Alternative name: DETC (high purity), Diethyldithiocarbamate (high purity). Purity: ≥99% (Titration). Solubility: Soluble in water (20mg/ml). Long Term Storage: +4°C.
Enzo Life Sciences Carboxy-PTIO (50mg). CAS: 148819-94-7
Water soluble and stable nitric oxide radical scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical (NO·). The inhibitory effects were almost 2-fold stronger than those of NMMA (ALX-106-001) and NOARG (ALX-105-001). Reacts with nitric oxide in a stoichometric manner. Can be used for an improved detection of nitric oxide in activated macrophage cultures in combination with the Griess reagent (ALX-400-004). Protects against endotoxin shock. Alternative name: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide . potassium salt. Purity: ≥99% (HPLC). Solubility: Soluble in 100% ethanol, methanol, DMSO or dimethyl formamide. Highly soluble in water or aqueous buffers, e. g. PBS, pH 7.2. Long Term Storage: -20°C.
Enzo Life Sciences TEMPONE-H. hydrochloride (10mg). CAS: 3637-11-4
Very effective, cell permeable and non-toxic spin trap for the detection of superoxide radical and peroxynitrite. Alternative name: 1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine . HCl. Purity: ≥99% (GLC). Appearance: White to off-white crystalline powder. Solubility: Soluble in DMSO, water, methanol or 100% ethanol. Long Term Storage: -20°C.
Enzo Life Sciences CMH. hydrochloride (10mg)
Analog of CPH (ALX-430-078) with higher cell permeability and 3-fold better reactivity with superoxide. Has been used to study intracellular production of superoxide radicals in plasma, endothelial cells and isolated hearts. Alternative name: 1-Hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine . HCl. Purity: ≥99% (EPR). Appearance: White to light-yellow crystalline powder. Solubility: Soluble in DMSO, 100% ethanol, methanol or water. Long Term Storage: -20°C.
Enzo Life Sciences Zoledronic acid (100mg). CAS: 165800-06-6
Inhibitor of osteoclastic bone resorption. Prevents osteoporosis and skeletal fractures, particularly in patients with multiple myeloma or prostate cancer. Also used to treat hypercalcemia. Inhibition of acid sphingomyelinase (aSMase) with an IC50 5µm. Alternative name: 1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid, CGP 42446. Purity: ≥98% (HPLC). Solubility: Soluble in 0.1N NaOH. Sparingly soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences POBN (high purity) (1g). CAS: 66893-81-0
Cell permeable hydrophilic spin trap for both in vivo and in vitro studies. Water soluble analog of PBN (ALX-430-082). Low paramagnetic impurities. No further purification required. Alternative name: alpha-(4-Pyridyl 1-oxide)-N-tert-butylnitrone. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO, water, methanol or 100% ethanol. Long Term Storage: -20°C.
Enzo Life Sciences A771726 (25mg). CAS: 108605-62-5
Physiologically active metabolite of the immunosuppressive drug leflunomide (ALX-430-095). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of cyclooxygenase-2 (COX-2) in vitro and in vivo. Alternative name: N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide. Purity: ≥98% (HPLC). Appearance: White solid. Solubility: Soluble in DMSO. Long Term Storage: +4°C.
Enzo Life Sciences Zoledronic acid (1g). CAS: 165800-06-6
Inhibitor of osteoclastic bone resorption. Prevents osteoporosis and skeletal fractures, particularly in patients with multiple myeloma or prostate cancer. Also used to treat hypercalcemia. Inhibition of acid sphingomyelinase (aSMase) with an IC50 5µm. Alternative name: 1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid, CGP 42446. Purity: ≥98% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in 0.1N NaOH. Sparingly soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences Hecameg (1g). CAS: 115457-83-5
Non-ionic, glucose based very mild detergent for membrane protein purification. Alternative name: 6-O-(N-Heptylcarbamoyl)-methyl-alpha-D-glucopyranoside. Purity: ≥98% (HPLC). Solubility: Soluble in water (>100mg/ml at +4°C). Long Term Storage: +4°C.
Enzo Life Sciences LPS from E. coli, Serotype J5 (Rc) (TLRGRADE™) (Ready-to-Use) (2ml)
Alternative name: Lipopolysaccharide from E. coli, Serotype J5 (Rc). Formulation: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water. Purity: Absence of detectable protein or DNA contaminants with agonistic TLR activity. Long Term Storage: +4°C.
Enzo Life Sciences (2R,4R)-APDC (5mg). CAS: 169209-63-6
Selective agonist for group II mGluRs. Inhibits the NADPH-oxidase dependent ROS system. Alternative name: LY-314,593, (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid. Purity: ≥98% (HPLC). Appearance: Off-white powder. Solubility: Soluble in water. Long Term Storage: Ambient.