Unsubstituted Phenols
Unsubstituted Phenols
Enzo Life Sciences Tyrphostin 47 (RG-50864) (AG-213) (5mg). CAS: 122520-86-9
A potent inhibitor of EGF receptor kinase activity (IC50‘s:EGFR = 2.4 µM, PDGFR = 3.5 µM, p210bcr-abl=5.9 µM, insulin receptor = 640 µM). Purity: ≥99% (TLC). Solubility: Soluble at 20 mg/ml in 100% ethanol or DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin 1 (20mg). CAS: 2826-26-8
An inactive tyrphostin, which may be used as a negative control. Purity: ≥99%. Solubility: Soluble in 100% ethanol (25mg/ml, warm) or DMSO (25mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences ZM 336372 (25mg). CAS: 208260-29-1
Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells. Alternative name: N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide. Purity: ≥95% (HPLC). Solubility: Soluble in DMSO (200mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin 25 (RG-50875) (5mg). CAS: 118409-58-8
A potent inhibitor of EGF receptor kinase activity (IC50=3 µM). Purity: ≥99%. Solubility: Soluble in 100% ethanol or DMSO. Long Term Storage: Ambient.
Enzo Life Sciences Mycophenolate mofetIL-(100mg). CAS: 128794-94-5
Mycophenolate mofetil (CellCept) is an immunosuppressant prodrug of mycophenolic acid, a fermentation product of Penicillium brevicompactum. Immunosuppression occurs via inhibition of type II inosine-5’-monophosphate dehydrogenase, depleting guanosine preferentially in T and B lymphocytes. In addition, mycophenolic acid displays anti-inflammatory activity by preventing NO production specifically from iNOS and by blocking glycosylation and expression of adhesion molecules and therefore recruitment of lymphocytes and monocytes to sites of inflammation. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml, warm). Long Term Storage: Ambient.
Enzo Life Sciences L-Thiocitrulline . dihydrochloride (50mg). CAS: 212051-53-1
Inhibitor of neuronal (nNOS; NOS I; Ki=60nM) and inducible (iNOS; NOS II) nitric oxide synthase. Formula: C6H13N3O2S . 2HCl. MW: 191.3 . 72.9. Purity: ≥97% (TLC). Appearance: White solid. Solubility: Soluble in water or DMSO. Long Term Storage: +4°C.
Enzo Life Sciences Tyrphostin AG 1295 (5mg). CAS: 71897-07-9
PDGF inhibitor. Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor. Alternative name: 6,7-Dimethyl-2-phenylquinoxaline. Formula: C16H14N2. MW: 234.3. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C. Handling: Store tightly sealed in the dark. Protect from light.
Enzo Life Sciences Tyrphostin AG 527 (25mg). CAS: 133550-32-0
Alternative name: Tyrphostin B44, (-)-(R)-N-(alpha-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide. Formula: C18H16N2O3. MW: 308.3. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO or 100% ethanol. Long Term Storage: -20°C. Handling: Store tightly sealed in the dark. Protect from light.
Enzo Life Sciences Phloretin (200mg). CAS: 60-82-2
Flavonoid. Protein kinase C (PKC) inhibitor. PGF2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca2+ levels. Inhibits myo-inositol uptake and 5’-iodothyronine deiodinase. Prevents TNF-α stimulated upregulation of VCAM-1, ICAM-1 and E-selectin. Enhances adiponectin expression. Purity: ≥98% (TLC). Solubility: Soluble in acetone, DMSO, 100% ethanol or methanol. Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin 51 (5mg). CAS: 122520-90-5
A potent inhibitor of EGF receptor kinase activity (IC50=0.8 µM). Inhibition is mixed competitive with ATP and substrate. Purity: ≥99%. Solubility: Slightly soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences ZM 336372 (5mg). CAS: 208260-29-1
Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells. Alternative name: N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide. Purity: ≥95% (HPLC). Solubility: Soluble in DMSO (200mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences 10-Hydroxycamptothecin (20mg). CAS: 64439-81-2
A DNA topoisomerase I inhibitor that induces differentiation in HL-60 cells. It induces apoptosis in human breast cancer cell lines MCF-7 and MDA-MB-468. Purity: ≥97%. Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin 8 (10mg). CAS: 3785-90-8
The tyrphostins are well known tyrosine kinase inhibitors. However, tyrphostin 8 has been shown to inhibit calcineurin (IC50=21 µM) while displaying weak inhibition of EGFR tyrosine kinase (IC50=560 µM). Alternative name: alpha-Cyano-(4-hydroxy)cinnamonitrile. Purity: ≥98% (TLC). Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences 10-Hydroxycamptothecin (100mg). CAS: 64439-81-2
A DNA topoisomerase I inhibitor that induces differentiation in HL-60 cells. It induces apoptosis in human breast cancer cell lines MCF-7 and MDA-MB-468. Purity: ≥97%. Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Tyrphostin 23 (RG-50810) (10mg). CAS: 118409-57-7
A potent inhibitor of EGF receptor kinase activity (IC50=35 µM). Alternative name: alpha-Cyano-(3,4-dihydroxy)cinnamonitrile. Purity: ≥99% (TLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). Long Term Storage: Ambient.
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