Specially adapted for use with the Nanoliter Injector for oocyte injection and similar applications, this joystick-controlled micromanipulator allows an easy “steering” motion that translates normal hand movement into smooth sub-millimeter shifts. Viewed microscopically, movement of the tool-tip corresponds naturally to hand movement, so accurate resolution is intuitive and quick. All fine adjustment can be controlled by the joystick. Pivoting forward, backward or laterally gives precise x-y adjustment. For added convenience, a separate coarse control lever is also provided for quick raising and lowering. A stop screw, which is set once resolution is achieved, eliminates refocusing and streamlines repetitive work by guiding the tip to its previous focusing plane.