Search results for "Enzo Life Sciences"
Enzo Life Sciences Streptozotocin, (1g), CAS Number: 18883-66-4
O-GlcNAcase inhibitor. Widely used diabetes inducer in rodents. Inhibition of β-cell O-GlcNAcase by streptozotocin is the mechanism that accounts for its diabetogenic toxicity. N-nitroso-containing antibiotic, acting as a nitric oxide (NO) donor and vasorelaxant. Relaxes phenylephrine-contracted aortic rings at 10µM. Potent methylating agent for DNA. Alternative Name: Streptozocin, 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose, STZ. Formula: C8H15N3O7. MW: 265.2. CAS Number: 18883-66-4. MI: 14: 8832. Purity: ≥97% (Assay). Appearance: White to pale yellow crystalline solid. Solubility: Soluble in water (nH2O at 102.8mg/ml) or 100% ethanol (200 proof at 0.92mg/ml). Use/Stability: Because solutions of the compound spontaneously give off NO gas at room temperature, we recommend that solutions be made immediately before use. Long Term Storage: -20°C
Enzo Life Sciences BIOMOL Green (1x1L)
A simple and convenient method for colorimetric phosphate quantitation. Applications: FUNC. Colorimetric detection, HTS. Contents: Biomol Green Reagent (Prod. No. BML-AK111) (1l or 250ml; liquid in screw cap plastic bottle) Storage: room temperature. Long-term at 4°C; can be stored frozen without deleterious effects. Phosphate Standard (Prod. No. BML-KI102) (1ml; 800µm phosphate in distilled water) Storage: room temperature. Long-term at 4°C; can be stored frozen without deleterious effects.
Enzo Life Sciences alpha Gal Epitope (Galalpha1-3Galbeta1-4GlcNAc-R) monoclonal antibody (M86) (1 Vial)
Clone: M86. Host: Mouse. Isotype: IgM. Immunogen: Rabbit red blood cell membrane. Source: Hybridoma tissue culture. Species Reactivity: Mouse, Rat, Porcine. Specificity: Recognizes synthetic and naturally produced mouse, rat and pig Galα1-3Gal epitopes on glycoproteins and glycolipids. Crossreactivity: Does not cross-react with β-Gal glycoproteins or BSA. Applications: ELISA. Flow Cytometry, IHC (PS), WB. FUNC. Recommended dilutions: Note: Do not use non-fat milk for blocking! Many blocking agents from non-human mammal. Sources will cross-react with the antibody. Appropriate antibody dilution may vary from lot to lot. An initial dilution of 1:5 is recommended. Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. Formulation: Liquid. Tissue culture supernatant. Handling: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Enzo Life Sciences IM-12, (5mg), CAS Number: 1129669-05-1
GSK-3β inhibitor (IC50=53nM (enzymatic), 3.8µM (cellular)). The compound significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling. Alternative Name: 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Formula: C22H20FN3O2. MW: 377.4. CAS Number: 1129669-05-1. Purity: ≥98% (HPLC). Appearance: Orange solid. Solubility: Soluble in DMSO (25 mg/ml) or in 100% ethanol (5 mg/ml). Use/Stability: Store as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. Long Term Storage: -20°C
Enzo Life Sciences IHC PAP pen (1 ea)
The IHC PAP pen provides a hydrophobic barrier when a circle is drawn around a specimen on a glass slide. Applications: IF, IHC, ISH (in situ hybridization). Shipping: Ambient. Long Term Storage: Ambient
Enzo Life Sciences DiOC6(3) iodide (ultra pure), (100mg), CAS Number: 53213-82-4
Mitochondria dye . Alternative Name: 3,3'-Dihexyloxacarbocyanine iodide. MW: 572.5. CAS Number: 53213-82-4. Purity: ≥95% (HPLC). Solubility: Soluble in DMSO. Use/Stability: Stable for at least one year after receipt when stored as recommended. Long Term Storage: -20°C
Enzo Life Sciences PROTEOSTAT Aggresome detection kit (1x25tests)
Robust, quantitative detection of aggresomes relevant to the study of neurodegenerative disease, liver disease and toxicology. Aggresomes are inclusion bodies of aggregated, misfolded proteins that form when the ubiquitin-proteasome protein-degradation machinery is overwhelmed. Typically, aggresomes form in response to cellular stress and provide a cytoprotective mechanism by isolating misfolded proteins, leading ultimately to their clearance by autophagy. Protein aggregate formation is furthermore a hallmark of a variety of human diseases, such as Alzheimer's, Parkinson's, Amyotrophic lateral sclerosis or alcoholic liver disease.The PROTEOSTAT.PROTEOSTAT. . Applications: Flow Cytometry. Fluorescence microscopy. Fluorescent detection. Contents: PROTEOSTATAggresome detection reagent . Hoechst 33342 Nuclear stain. Proteasome Inhibitor (MG-132). 10X Assay Buffer
Enzo Life Sciences ALK5 Inhibitor II, (5mg), CAS Number: 446859-33-2
Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50>16µM). Alternative Name: TGF-beta RI Kinase Inhibitor II. 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine. Formula: C17H13N5. MW: 287.3. CAS Number: 446859-33-2. Purity: ≥97% (HPLC). Appearance: White to off-white or yellow solid. Solubility: 5mg/ml soluble in DMSO or methanol. Use/Stability: Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 6 months when stored at -20°C. Long Term Storage: -20°C
Enzo Life Sciences p62 ELISA kit (1x96wells)
Highly validated, quantitative p62 ELISA kit available for autophagy research. The p62 ELISA kit is a colorimetric, immunometric immunoassay kit with results in 3 hours. Alternative Name: Sequestosome 1. Sensitivity: 100pg/ml (range 625 - 40,000pg/ml). Assay Time: 3 hours. Applications: ELISA, Colorimetric detection. Species Reactivity: Human, Mouse, Rat. Contents: Microtiter Plate, Antibody, Conjugate, Assay Buffer 13, Wash Buffer Concentrate, Standard, TMB Substrate, Stop Solution 2, RIPA Cell Lysis Buffer 2
Enzo Life Sciences LPS from E. coli, Serotype R515 (Re) (TLRGRADE) (Ready-to-Use), (1ml)
TLR4 activator. Alternative Name: Lipopolysaccharide from E. coli, Serotype R515 (Re). Purity: Absence of detectable protein or DNA contaminants with agonistic TLR activity. Use/Stability: Stable for at least 1 year after receipt when stored at +4°C. Long Term Storage: +4°C
Enzo Life Sciences MEGACD40L Protein (soluble) (human), (recombinant) (10 µg)
High activity, high purity CD40L protein for co-stimulatory activation of an immune response. MEGACD40L. in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations (Prod. No. ALX-850-064). Alternative name: CD40L, CD154, TNFSF 5, gp39. MW: ~38kDa. Concentration: 0.1mg/ml after reconstitution. Endotoxin content: ≤0.01EU/µg purified protein (LAL test; Cape Cod Associates). Purity: ≥90% (SDS-PAGE). Formulation: Lyophilized. Contains PBS. Source: Produced in CHO cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG-tag. Use/Stability: Stable for at least 6 months after receipt when stored at -20°C. UniProt: P29965 (human CD40L), Q60994 (mouse Adiponectin). Handling: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. Long Term Storage: -20°C
Enzo Life Sciences Gramicidin A (5 mg) CAS: 11029-61-1
Ionophore antibiotic. Naturally occurring ion channel forming pentadecapeptide. Causes K+/H+-exchange in mitochondria in a non-voltage dependent manner. Formula: C99H140N20O17. MW: 1882.3. CAS: 11029-61-1. MI: 14: 4532. Purity: ≥90% (HPLC). Sequence HCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH2CH2OH. Appearance: White to off-white powder. Solubility: Soluble in DMSO, lower alcohols or acetic acid. Long Term Storage: -20°C
Enzo Life Sciences PAPG 5- PHOSPHOADENYLYL- 1UMOL
pApG: 5'- Phosphoadenylyl- (3' −> 5')- guanosine ( pApG / 5'-p(rA)p(rG) ), sodium salt, 1umol, 5064-50-6
Enzo Life Sciences Antimycin A, (10mg), CAS Number: 1397-94-0
Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1. Alternative Name: Antipiricullin, Virosin. CAS Number: 1397-94-0. MI: 14: 714 (A1) & 715 (A3). Appearance: White to faint yellow powder. Solubility: Soluble in 100% ethanol (50mg/ml). Long Term Storage: -20°C
Enzo Life Sciences Caspase-3 (human), (recombinant) (5000 U)
Alternative name: CPP32. Yama. Apopain. MW: 17 + 12 kDa. Concentration: 100 U/µl. Purity: ≥95% (SDS-PAGE). Formulation: Liquid. In 50mM HEPES, pH 7.4, 100mM sodium chloride, 0.5% CHAPS, 1mM EDTA, 10% glycerol and 10mM dithiothreitol. Source: Produced in E. coli. Caspase-3 (CPP32; Yama; apopain) from human cDNA. The enzyme was cleaved and activated from the proenzyme UniProt: P42574. Handling: Avoid freeze/thaw cycles. Long Term Storage: -80°C