Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
The Silencer™ Select Human Long Noncoding RNA (lncRNA) siRNA Library contains 15,081 Ambion™ Silencer Select siRNAs targeting 5,027 lncRNAs as identified in GENCODE v22.
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Ion channels are key components in a multitude of biological processes, including rapid changes in muscle cell contractions, epithelial transport of nutrients and ions, T cell activation and pancreatic beta-cell insulin release.
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DNA surveillance proteins monitor DNA integrity, and they can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. This can prevent potentially deleterious mutations.
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The Silencer™ Select Human Epigenetics siRNA Library contains 1563 Ambion™ Silencer Select highly potent, chemically-modified siRNAs targeting 521 epigenetic enzymes, including those mediating epigenetic signaling through the acetylation and methylation of histones.
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