PAP GnomePen liquid blocker is a proprietary formulation that is applied around the tissue sections on a microscope slide prior to immunohistochemistry. It dries in less than one minute! PAP GnomePen Liquid Blocker creates a thin visible hydrophobic film around tissue sections to reduce the amount of reagent needed for tissue coverage and stain reaction. GnomePen has one of the thinnest PAP pen tips available, allowing for adjacent circles, lines or a drawn pattern to be applied on a single slide. GnomePen contains a unique formulation that is water repellent, insoluble in alcohol and acetone, soluble in xylene and is insensitive to detergents (Triton X-100, Tween 20), varying pH and temperature. The GnomePen Classic PAP Pen is optimized for tissue sections between 4-20 microns thick. Estimated coverage would be for approximately 350 slides. Also available in Red, Green, Orange, Violet and Yellow.