Mass-Tagged Crosslinkers
Mass-Tagged Crosslinkers
Cayman Chemical HypoxnthIn-d4 50mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids intended for research and forensic applications
Cayman Chemical HypoxnthIn-d4 10mg
A nitric oxide-donating derivative of 17-phenyl trinor PGF2a reduces IOP in a rabbit model of hypertonic saline-induced transient ocular hypertension at 0 14 reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension at 0 042
Cayman Chemical HypoxnthIn-d4 25mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids intended for research and forensic applications
Cayman Chemical L-KynurenIn-d4 5mg
A nitric oxide-donating derivative of 17-phenyl trinor PGF2a reduces IOP in a rabbit model of hypertonic saline-induced transient ocular hypertension at 0 14 reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension at 0 042
Cayman Chemical N-NItrosonrnIcotIn-d4 10mg
A carbohydrate starting material has been used as a starting material in the synthesis of L-nucleoside-based anti-HIV agents
Cayman Chemical AloIsolIthocholIc AcId-d4 5mg
A PDE4D negative allosteric modulator (IC50 28 nM for the human enzyme) selective for PDE4D over PDE4B (IC50 562 nM for the human enzyme) as well as 14 other PDE isoforms (IC50s 1.4 UM) decreases forskolin-induced cAMP hydrolysis in HEK293 cells (IC50 253 nM) and dextran gel-induced increases in leukotriene E4 production in isolated human whole blood (IC50 44 nM) impairs novel object recognition in mice at 3 mg/kg but does not increase anesthesia duration a proxy measure of emesis induction in mice at 3 or 10 mg/kg
Cayman Chemical MoclobemIde-d4 25mg
An ASIC3 activator (EC50 67 UM for evoking rapid inward currents in ASIC3-expressing CHO cells at neutral pH) an inhibitor of the GABAA receptor (IC50 0.39 UM in primary rat hippocampal neurons) increases paw licking time in Asic3 / and to a lesser extent Asic3-/- mice at 100 UM
Cayman Chemical Dexamethason-d4 10mg
A quinolone antibiotic active against E coli Pasturella K pneumoniae A aerogenes Proteus Salmonella and Shigella (MBCs 0 5-25 Ug/ml) increases survival in mouse models of systemic K pneumoniae A aerogenes Proteus or Salmonella infection (ED50s 60 35 50 and 62 mg/kg respectively)
Cayman Chemical AbIrateron Acetate-d4 5mg
A P2Y12 receptor antagonist inhibits collagen- arachidonic acid- and ADP-induced aggregation of human platelets (IC50s 75 600 and 1300 M respectively) inhibits ADP-induced aggregation of rat platelets decreases thrombus weight in a rat model of arterio-venous shunt thrombosis at 100 mg/kg inhibits healing of acetic acid-induced gastric ulcers in rats at 300 mg/kg
Cayman Chemical S-AdenosylhomocysteIn-d4 5mg
Recombinant SARS-CoV-2 N-terminal His-tagged nsp10 expressed in E. coli Amino acids 1-139 (full length)
Cayman Chemical CholIc AcId-d4 5mg
An NHE-1 inhibitor (IC50 0 56 UM in an intracellular pH recovery assay) selective for NHE-1 over NHE-2 (IC50 28 UM in an intracellular pH recovery assay) inhibits sodium propionate-induced swelling of isolated human platelets (IC50 0 023 UM) reduces the myocardial infarct size as a percentage of the area at risk in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion at 1 mg/kg decreases ventricular tachycardia duration in a rat model of coronary artery ligation and reperfusion-induced arrhythmia at 1 mg/kg
Cayman Chemical HyocholIc AcId-d4 5mg
A naphthoquinone with diverse biological activities enantiomer of shikonin selectively inhibits tumor-specific PKM2 (IC50 0 3 M) over PKM1 and PKL inhibits proliferation of HCT116 and SW480 colorectal cancer cells (IC50s 2 38 and 4 53 M respectively) halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells at 3 M increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells at 1 M active against methicillin-sensitive and -resistant S aureus (MICs 6 25 g/ml) as well as vancomycin-sensitive and -resistant E faecalis (MICs 50 and 25 g/ml respectively) scavenges DPPH radicals in a cell-free assay (EC50 22 ppm)
Cayman Chemical Sulfamethoxazole-d4 25mg
A histamine H3 receptor agonist inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats from 0 25-2 mg/kg inhibits gastric acid secretion in rats when administered intracerebroventricularly from 0 5-50 nmol reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice respectively decreases freezing time in a conditioned fear stress test in rats acts synergistically with fentanyl to reduce nociception and plasma extravasation in a mouse model of chronic inflammation induced by complete Freunds adjuvant
Cayman Chemical ChenodeoxycholIc AcId-d4 5mg
A phenethylamine whose physiological and toxicological properties have not been investigated intended for research and forensic applications