Guinea Pig Whole Blood
Guinea Pig Whole Blood
Cayman Chemical DocosahexaenoIc ACD ethyl S
An agonist of LXRa and LXRB induces transactivation of LXRa and LXRB in reporter assays using HEK293T cells (EC50s 0.15 and 0.53 UM respectively) increases protein levels of ABCG1 and ABCA1 in RAW 264.7 and THP-1 cells at 1 or 10 UM induces cholesterol efflux and reduces oxidized LDL-induced lipid accumulation in RAW 264.7 cells at 1 or 10 UM
Cayman Chemical ArachIdonIc ACD methyl STR
A phenolic glycoside with diverse biological activities scavenges hydrogen peroxide- and iron-induced hydroxyl- and superoxide anion radicals in cell-free assays (IC50s 1.39 and 2.49 mM respectively) increases proliferation Alp activity and levels of collagen I and Runx2 in primary mouse osteoblasts at 100 nM prevents dexamethasone-induced decreases in femur bone mass density and volume in mice at 20 mg/kg per day reduces immobility time in the forced swim test and serum levels of corticosterone in a rat model of chronic unpredictable stress-induced depression at 1.5 3 or 6 mg/kg increases the number of entries into and time spent in the open arms of the elevated plus maze in mice at 5 10 or 20 mg/kg
Cayman Chemical 3 4 5TrImthoxybenzoIc ACD 100g
A furoquinoline alkaloid with diverse biological activities inhibits human AChE (IC50 8 6 Ug/ml) active against P falciparum (IC50 48 2 Ug/ml) active against the fungus L gongylophorus reduces TPA-induced ear edema in mice (ED45 0 75 mg/ear)
Cayman Chemical 3 4 5TrImthoxybenzoIc ACD 250g
A furoquinoline alkaloid with diverse biological activities inhibits human AChE (IC50 8 6 Ug/ml) active against P falciparum (IC50 48 2 Ug/ml) active against the fungus L gongylophorus reduces TPA-induced ear edema in mice (ED45 0 75 mg/ear)
Cayman Chemical ArachIdonIc ACD 1 2 3 4 513
A pan Akt inhibitor (Ki 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction
Cayman Chemical DocosapentaenoIc ACD ethyl50mg
An active metabolite of losartan inhibits arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 10 pM a PPARY agonist (EC50 17 1 UM in COS-7 cells expressing human PPARY using a reporter assay) increases lipid accumulation in 3T3-L1 adipocytes at 10 UM decreases superoxide production by NOX in isolated human PBMCs in a concentration-dependent manner inhibits LPS-induced increases in COX2 mRNA expression and LPS- or angiotensin II-induced increases in supernatant PGF2a levels in HUVECs at 10 UM
Cayman Chemical DocosapentaenoIc ACD ethyl10mg
An active metabolite of losartan inhibits arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 10 pM a PPARY agonist (EC50 17 1 UM in COS-7 cells expressing human PPARY using a reporter assay) increases lipid accumulation in 3T3-L1 adipocytes at 10 UM decreases superoxide production by NOX in isolated human PBMCs in a concentration-dependent manner inhibits LPS-induced increases in COX2 mRNA expression and LPS- or angiotensin II-induced increases in supernatant PGF2a levels in HUVECs at 10 UM
Cayman Chemical PalmItoleIc ACD methyl STR
A prodrug form of imidaprilat inhibits swine renal cortex ACE activity in vitro (IC50 9 9 UM) inhibits the angiotensin I-induced pressor response in normotensive rats decreases blood pressure in spontaneously hypertensive and 2K-1C renal hypertensive rats at 2 mg/kg decreases stroke incidence and increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet reduces urinary albumin excretion in a mouse model of streptozotocin-induced diabetes at 5 mg/kg
Cayman Chemical DocosatrIenoIc ACD methyl25mg
A second messenger that is biosynthesized from GTP by guanylate cyclases activates protein kinase G (PKG) and modulates ion channel conductance with signaling affecting diverse processes including smooth muscle relaxation and proliferation phototransduction and energy homeostasis
Cayman Chemical DeuTRated ArachIdonIc ACD C
An orally bioavailable SARM that binds to the androgen receptor with a Ki value of 7 nM stimulates muscle weight increase without affecting prostate or seminal vesicle in castrated male rats
Cayman Chemical GlycohyodeoxycholIc ACD MaxS
Immunogen Recombinant mouse Olig2 Host Rabbit Species Reactivity ( ) Human mouse rat Applications ICC IHC IP WB MW 32 kDa
Cayman Chemical compre Faty ACD Meth 1mL
A dual inhibitor of PI3K and mTOR (IC50s 3 4 12 16 and 16 nM for PI3Ka PI3KB PI3K and PI3KY respectively) inhibits proliferation of PC3 and MCF-7 1 cells (IC50s 330 and 180 nM respectively) reduces tumor volume in PC3 and MCF-7 1 mouse xenograft models at 10 mg/kg per day
Cayman Chemical 4AmInobenzoIc ACD hydrazID
A prodrug form of remogliflozin A inhibits human SGLT2 and SGLT1 (Kis 1.95 and 43.1 M respectively) inhibits increases in plasma glucose levels in a glucose tolerance test in a rat model of STZ-induced diabetes at 3 and 10 mg/ml increases fasting plasma insulin levels and reduces fasting plasma glucose and triglyceride levels as well as urinary glucose excretion in a db/db mouse model of diabetes with hyperinsulinemia and obesity at 10 and 30 mg/kg twice per day for 6 weeks
Cayman Chemical DocosapentaenoIc ACD ethyl1mg
A selective short-acting adenosine A2A receptor agonist (Ki 1 1 nM for pig striatum A2A receptor) used to induce hyperemia particularly in the context of myocardial perfusion imaging