Indoles and derivatives
Indoles and derivatives
Enzo Life Sciences PD-146176 (50mg). CAS: 4079-26-9
A potent and selective 15-lipoxygenase inhibitor which lacks significant nonspecific antioxidant properties. It suppresses atherogenesis and limits atherosclerotic lesion development in the rabbit. It reduces oxidant stress-induced apoptosis in endothelial cells and inhibits proliferation in 15-LO overexpressing PC3 cells. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (50mg/mL) and ethanol (10mg/mL). Long Term Storage: Ambient.
Enzo Life Sciences Wiskostatin (1 mg). CAS: 253449-04-6
A selective, reversible inhibitor of N-WASP (neural Wiskott-Aldrich syndrome protein) that selectively blocks actin filament assembly. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex. Purity: ≥98% (HPLC). Solubility: Soluble in ethanol (10 mg/ml with warming) or DMSO (25 mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences Wiskostatin (5 mg). CAS: 253449-04-6
A selective, reversible inhibitor of N-WASP (neural Wiskott-Aldrich syndrome protein) that selectively blocks actin filament assembly. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex. Purity: ≥98% (HPLC). Solubility: Soluble in ethanol (10 mg/ml with warming) or DMSO (25 mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences PD-146176 (10mg). CAS: 4079-26-9
A potent and selective 15-lipoxygenase inhibitor which lacks significant nonspecific antioxidant properties. It suppresses atherogenesis and limits atherosclerotic lesion development in the rabbit. It reduces oxidant stress-induced apoptosis in endothelial cells and inhibits proliferation in 15-LO overexpressing PC3 cells. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (50mg/mL) and ethanol (10mg/mL). Long Term Storage: Ambient.