Dipolar organic compounds characterized by having delocalized electrons with charge separation over three atoms. Commonly used as reactants in 1,3-dipolar cycloaddition reactions.
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A medium-chain saturated fatty acid a non-competitive antagonist at AMPA receptors selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2/3 subunit-containing AMPA receptors (IC50 0 52 mM) over those expressing GluA1 (IC50 2 09 mM) or GluA1/2 subunits (IC50 1 16 mM) inhibits epileptiform activity induced by pentylenetetrazole or low magnesium in rat hippocampal slices induces contractions in isolated guinea pig duodenum at 1 mM increases the escape threshold in an orofacial mechanical stimulation test in rats when administered as a 30 topical ointment plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer
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An inhibitor of cathepsin B (Ki 2.7 nM) inhibits cell division cell cycle progression DNA replication and chromosome decondensation in isolated T. niger fertilized embryos at 100 UM prevents AB40-induced increases in cathepsin L activity as well as prevents AB40-induced apoptosis DNA fragmentation and increases in cleaved PARP levels in primary rat cortical neurons at 10 UM inhibits quinolinic acid-induced nuclear translocation of NF-KB as well as inhibits quinolinic acid-induced increases in phosphorylated IKBa and IKKa levels in the unilateral striatum in rats at 5 nmol/animal
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