Thermo Scientific Chemicals Temsirolimus, 99+%

Description

A Rapamycin derivative with anti-cancer activity that inhibits mTOR

Temsirolimus is used as a rapamycin derivative with anti-cancer activity that inhibits mTOR. Temsirolimus is an antiproliferative and antiangiogenic, the first-in-class mTOR inhibitor approved for the treatment of patients with advanced poor prognosis renal cell carcinoma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 162635-04-3
• Molecular Formula: C₅₆H₈₇NO₁₆, C56H87NO16

• Quantity: 50 mg
• Description: White to Off-white
• Content And Storage: -30°C to -10°C
• For Use With (Application): A Rapamycin derivative with anti-cancer activity that inhibits mTOR
• Formula Weight: 1030.29g/mol
• Product Type: Signal Transduction Reagent
• Form: Powder
• MDL Number: MFCD00934421
• InChI Key: CBPNZQVSJQDFBE-QYCDWSQESA-N
• SMILES: [H]C12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C(C)[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OC(=O)C(C)(CO)CO)[C@@H](C1)OC
• IUPAC Name: (1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,18R,19R,21R,23S,30S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0⁴,⁹]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• Molecular Weight (g/mol): 1030.30
• Assay: ≥99%

Safety and Handling

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only