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  5. Tocris Bioscience™ LSN 2463359
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Tocris Bioscience™ LSN 2463359

Potent and selective positive allosteric modulator at mGlu5

Supplier:  Tocris Bioscience™ 5275/50

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Catalog No. 52-755-0


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Description

Description

LSN 2463359 is a potent and selective positive allosteric modulator at the mGlu5 receptor (EC50 = 24 nM). Has no activity at mGlu1-4, mGlu8 and GABAB receptors. Reverses methylazoxymethanol acetate (MAM)-induced deficits in reversal learning memory and normalizes SDZ 220-581 and RO 63-1908 -induced alterations in instrumental responses in rat models. Promotes wakefulness in vivo. Brain penetrant and orally active.
Specifications

Specifications

>99%
LSN 2463359
LSN 2463359
50 mg
265.31
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