Thermo Scientific™ DSS (disuccinimidyl suberate), No-Weigh™ Format

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Supplier:  Thermo Scientific™ A39267

Catalog No. PIA39267

Description

Thermo Scientific™ Pierce DSS, also called disuccinimidyl suberate, is noncleavable and membrane permeable crosslinker that contains an amine-reactive N-hydroxysuccinimide (NHS) ester at each end of an 8-carbon spacer arm.

• Reactive groups: NHS ester (both ends)
• Reactive towards: amino groups (primary amines)
• Amine reactive sulfo-NHS ester reacts rapidly with any primary amine-containing molecule
• Membrane-permeable, allowing for intracellular crosslinking
• High purity, crystalline reagent can be used to create high-purity conjugates
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO); compare to BS3 (Sulfo-DSS)

Specifications

• Chemical Reactivity: Amine-Amine
• Description: DSS
• PEGylated: No
• Content And Storage: Upon receipt store desiccated at 4°C.
• Shipping Condition: Ambient
• Labeling Method: Chemical Labeling
• Reactive Moiety: NHS Ester
• Form: Solid
• Solubility: DMF, DMSO
• Water Soluble: No

• Cleavable: No
• Molecular Weight (g/mol): 368.35
• Spacer Arm Length: 11.4 Å
• Cell Permeability: Yes
• Product Line: No-Weigh™
• Crosslinker Type: Homobifunctional
• Spacer: Medium (10 to 30 Å)
• Quantity: 10 x 2 mg
• Format: Standard, Single-use
• Product Type: Crosslinker