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CD25 (IL-2 Receptor α) Mouse, anti-Human, RB780, Clone: 2A3, BD Horizon™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 568689

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Catalog No. BDB568689


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Description

Description

The 2A3 monoclonal antibody specifically binds to human CD25, the low-affinity alpha subunit of the Interleukin-2 Receptor (IL- 2Rα). CD25 associates with CD122 (IL-2Rβ chain) and CD132 (common γ chain or γc) to form the high-affinity signal-transducing IL-2R complex. CD25 is expressed by subsets of thymocytes and peripheral blood lymphocytes including CD4+CD25+ regulatory T cells and memory T cells. CD25 antigen density increases on activated T cells including phytohemagglutinin (PHA)-, concanavalin A (Con A)-, and CD3-activated T lymphocytes. High levels of CD25 can be expressed by T lymphocytes from mixed lymphocyte cultures and by human T-lymphocyte leukemia virus (HTLV)-infected T-lymphocyte leukemia lines, for example, HUT-102. CD25 can also be expressed by activated B cells and macrophages. Recombinant IL-2 blocks the binding of the 2A3 antibody to PHA-activated T lymphocytes.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD25 (IL-2 Receptor α)
2A3
Aqueous buffered solution containing ≤0.09% sodium azide
Human Phytohemagglutinin-activated T Cells
RUO
3559
Refrigerate (2°C to 8°C)
Flow Cytometry
RB780
Mouse
25 Tests
Secondary
Human
IgG1 κ
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