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Tocris Bioscience™ AZD 7762 hydrochloride

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2

Supplier: Tocris Bioscience™ 5199/10

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Catalog No. 51-991-0

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Description

AZD 7762 hydrochloride is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC50 vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo. Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 μM).

Specifications

Purity	>98%
Product Type	AZD 7762 hydrochloride
Inhibitors	AZD 7762 hydrochloride

Quantity	10 mg
Molecular Weight (g/mol)	398.88

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Tocris Bioscience™ AZD 7762 hydrochloride

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