Benzene and substituted derivatives
Benzene and substituted derivatives
Enzo Life Sciences M344 (5mg). CAS: 251456-60-7
Potent inhibitor of histone deacetylases (HDACs) (IC50≤1µM). Alternative name: 4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)-benzamide. Formula: C16H25N3O3. MW: 307.4. Purity: ≥98% (HPLC). Appearance: White crystalline solid. Solubility: Soluble in DMSO (1mg/ml). Long Term Storage: +4°C. Handling: Protect from light.
Enzo Life Sciences AS-252424 (5mg). CAS: 900515-16-4
Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects. Alternative name: 5-[5-(4-Fluoro-2-hydroxyphenyl)-furan-2-ylmethylene)]-thiazolidine-2,4-dione. Purity: ≥98% (1H-NMR). Appearance: Yellow-green to brownish solid. Solubility: Soluble in 100% ethanol (10mg/ml), DMSO (20mg/ml) or dimethyl formamide; also soluble in a 1:1 solution of DMSO:PBS, pH 7.4, (0.5mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences CPH . hydrochloride (250mg). CAS: 92416-28-9 (non-salt)
Effective, cell permeable and non-toxic spin probe for the detection of superoxide radical and peroxynitrite, both in vitro and in vivo. Resistant to reduction by vitamin C and thiols. Alternative name: 1-Hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine . HCl. Purity: ≥99% (EPR). Solubility: Soluble in DMSO, 100% ethanol, methanol or water. Long Term Storage: -20°C.
Enzo Life Sciences CAT1H . hydrochloride (50mg)
Cyclic hydroxylamine spin probe for in vivo, intraperitoneal and intravenous injections. Lifetime of more than 4 hours in blood plasma, in cells and tissue. Allows quantitative measurements of extracellular O2•– and quantification of intracellular O2•– in cells and tissue samples and in vivo O2•– detection. Alternative name: 1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl-trimethylammonium chloride . HCl. Solubility: Soluble in water, methanol or 100% ethanol. Long Term Storage: -20°C.
Enzo Life Sciences HC-030031 (50mg). CAS: 349085-38-7
A potent and selective TRPA1 inhibitor. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25 mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences Sulindac sulfone (25mg). CAS: 59864-04-9
Induces apoptosis but does not inhibit cyclooxygenase. Inhibits growth and induces apoptosis in human cancer cell lines. Metabolite of Sulindac (ALX-430-105). Alternative name: Z-5-Fluoro-2-methyl-1-[p-(methyl-sulfonyl)benzylidene]indene-3-acetic acid. Purity: ≥94% (HPLC). Solubility: Soluble in DMSO (>25mg/ml) or 100% ethanol (3mg/ml, warm). Long Term Storage: Ambient.
Enzo Life Sciences BI-D1870 (5mg). CAS: 501437-28-1
Cell permeable, ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC50's at 100µM ATP: RSK1 = 31nM, RSK2 = 24nM, RSK3 = 18nM, RSK4 = 15nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. Acts on the N-terminal AGC kinase domain. Completely prevents PMA-induced TSC2 phosphorylation. Alternative name: 2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (>25mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences AH-6809 (5 mg). CAS: 33458-93-4
Selective prostaglandin E2 receptor (EP1) antagonist. Useful at concentrations up to 10 µM, at which point it starts to block PGD2 and TXA2 receptors. Purity: ≥98% (TLC). Solubility: Soluble in DMSO. Long Term Storage: Ambient.
Enzo Life Sciences Dabrafenib (free base) (200mg). CAS: 1195765-45-7
Dabrafenib is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Dacomitinib (free base) (25mg). CAS: 1110813-31-4
Dacomitinib is a potent, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Idelalisib (free base) (100mg). CAS: 870281-82-6
Idelalisib is a PI3K-δ inhibitor with potential immunomodulating and antineoplastic activities. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Dabrafenib (free base) (500mg). CAS: 1195765-45-7
Dabrafenib is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Dacomitinib (free base) (50mg). CAS: 1110813-31-4
Dacomitinib is a potent, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Idelalisib (free base) (200mg). CAS: 870281-82-6
Idelalisib is a PI3K-δ inhibitor with potential immunomodulating and antineoplastic activities. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Enzo Life Sciences Rucaparib phosphate (5mg). CAS: 459868-92-9
Rucaparib is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.