Peptides
Peptides
Eurofins Discoverx WKYMVm-NH2, 1 mg. (92-1075)
WKYMVm-NH2 is a peptide found in immune cells that is an agonist of formyl peptide receptors (FPR), with EC50 of 75 pM, 75 pM, and 3 nM for receptors 1, 2, and 3, respectively. It induces calcium mobilization, superoxide production, and chemotaxic migration in monocytes and neutrophils. Assists in neutrophil survival and stimulates phospholipase C (PLC) mediated InoP formation. Provided as 1 mg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx Angiotensin II, Human, 5 mg. (92-1077)
Angiotensin II is an endocrine, autocrine/paracrine, and intracrine hormone formed from the conversion of angiotensin I via angiotensin-converting enzyme (ACE). It increases blood pressure by vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis, and Gαq protein stimulation in vascular smooth muscle. Also acts as a Na/H exchanger in the proximal tubules of the kidney, increasing blood sodium content and leading to increased blood volume, pressure and pH. Thus ACE inhibitors are considered anti-hypertensives. Provided as 5 mg of dry powder alongside reconstitution buffer. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
![Eurofins Discoverx [Arg8]-Vasopressin acetate, 1 mg. (92-1105)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/92-1105.PNG-250.jpg)
Eurofins Discoverx [Arg8]-Vasopressin acetate, 1 mg. (92-1105)
[Arg8]-Vasopressin (also known as antidiuretic hormone, or ADH) is a naturally occurring antidiuretic peptide hormone that acts as a neurotransmitter in the brain and released from the posterior pituitary and median eminence. It is involved in water and electrolyte homeostasis, vasodepression, and memory. Provided as 1 mg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx Bradykinin, 5 mg. (92-1053)
Bradykinin is a peptide that acts as a mediator of pain and inflammation, with pro-inflammatory activity. It is an agonist of the bradykinin receptors, with selectivity for B2 receptor over B1. Important roles in fluid regulation, electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. A common target of blood pressure lowering drugs, increased levels of bradykinin may be associated with increased lung and gastric cancer risk. Provided as 5 mg of dry powder alongside reconstitution buffer. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
![Eurofins Discoverx [D-Ala2, D-Leu5]-Enkephalin (DADLE), 5 mg. (92-1055)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/92-1055.PNG-250.jpg)
Eurofins Discoverx [D-Ala2, D-Leu5]-Enkephalin (DADLE), 5 mg. (92-1055)
[D-Ala2, D-Leu5]-Enkephalin (DADLE) is a synthetic peptide that is a selective agonist of the delta opioid receptor, but also binds mu opioid receptors of subtype μ1. It has antinociceptive and analgesic properties via neuron protection, and in-vivo effects include reduction in arterial blood pressure and heart rate. Provided as 5 mg of dry powder alongside reconstitution buffer. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx PACAP (1-27), 0.5 mg. (92-1061)
Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) is an endogenous neuropeptide that stimulates adenylate cyclase and increases cAMP levels. It acts as a neurotransmitter and neuromodulator, and demonstrates stimulatory effects on sympathetic neuronal NPY and catecholamine production. Has considerable homology with vasoactive intestinal peptide (VIP). Acts as an agonist for ADCYAP1R1. Provided as 500 μg of dry powder alongside reconstitution buffer. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx GIP (Gastric Inhibitory Peptide), 500 µg. (92-1078)
Gastric inhibitory polypeptide (GIP) is a secretin family endocrine peptide hormone produced in the small intestine that induces insulin secretion in a glucose-dependent manner and in response to eating. It also weakly inhibits gastric acid secretion. Acts as an agonist for GIPR. Provided as 0.5 mg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx PTH(1-34), 500 µg. (92-1082)
Parathyroid hormone (PTH) is a polypeptide hormone secreted by the parathyroid that enhances bone calcium mobilization, enhances osteoblast activity (anabolic), increases blood calcium levels and calcium:phosphate ratio in the kidney, and promotes absorption of calcium by the intestines. The 1-34 amino acid fragment also induces BMP gene transcription. Agonist of the parathyroid hormone receptors PTH1 and PTH2. Provided as 500 μg of dry powder alongside reconstitution buffer. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx Luteinizing Hormone, 10 µg. (92-1112)
Luteinizing hormone (LH) is a pituitary reproductive hormone which acts in concert with follicle stimulating hormone. It regulates menstrual cycle by triggering ovulation and corpus luteum development in women. Also triggers production of testosterone by stimulating leydig cells in men. Acts as an agonist for LHCGR. Provided as 10 μg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx SLIGRL-NH2, 1 mg. (92-1124)
SLIGRL-NH2 is a 6 amino acid peptide derived from the N-terminus (aa 39-44) of protease-activated receptor-2 (PAR2). It activates PAR2 (EC50=~5 µM), stimulating gastric and intestinal smooth muscle contraction. Provided as 1 mg of dry powder alongside reconstitution buffer. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx αMSH, 1 mg. (92-1172)
α-Melanocyte stimulating hormone (α-MSH) is a pituitary hormone that plays a key role in appetite control and the skins UV protection and development of pigmentation. Also has effects on energy homeostasis, sexual activity, and as an anti-inflammatory. Potent agonist of the melanocortin receptors MC1, MC3, MC4, and MC5 (Ki=0.12, 31, 660, and 5700 nM, respectively), but not MC2. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx Neuromedin U-25, 500 μg. (92-1174)
Neuromedin U-25 is a 25 amino acid neuropeptide found in the human brain that has functions in smooth muscle contraction, blood pressure regulation, bone growth, pain perception, appetite, and hormone release. Isoforms of different lengths are found in different species. Found to be overexpressed in pancreatic cancers. Activates the neuromedin receptors nMU1R and nMU2R. Provided as 500μg of dry powder alongside reconstitution buffer. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx INSL 5 (Mouse), 20 µg. (92-1228)
Insulin-like peptide 5 (INSL5) is a heterodimer of the INSL5A and B peptide chains, and a member of the insulin/relaxin superfamily that is a potent agonist for the G protein-coupled receptor RXFP4. Possible roles include gut contractility, thymic development and regulation, food intake, and glucose homeostasis. Provided as 200 μg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
Eurofins Discoverx Secretin, 250 μg. (92-1181)
Secretin is a 27 amino acid GI peptide hormone acting as an agonist for SCTR. It is responsible for regulation of water homeostasis, secretions of the stomach and pancreas, and pH of the duodenum. May also play a role in osmoregulation of the hypothalamus, pituitary, and kidney. Provided as 250 μg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
![Eurofins Discoverx (Tyr[SO3]27) Cholecystokinin (26-33), 250 μg. (92-1152)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/92-1152.PNG-250.jpg)
Eurofins Discoverx (Tyr[SO3]27) Cholecystokinin (26-33), 250 μg. (92-1152)
(Tyr[SO3]27)CCK-8 (cholecystokinin) is an 8 amino acid GI peptide hormone and member of the CCK family that stimulates digestion of the fat and protein in the GI system. Research suggests it plays a role in opioid drug tolerance and hunger suppression. Agonist of the CCK A receptor. Provided as 250 μg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.