Peptides
Peptides
Enzo Life Sciences Autocamtide-2-related inhibitory peptide (myristoylated) (0.5mg)
Cell permeable CaM kinase II inhibitor. Corresponds to ALX-151-029 but this one is N-terminal myristoylated to increase cell permeability. Alternative name: AIP (myristoylated). Formula: C78H142N22O20. MW: 1708.1. Purity: ≥98%. Appearance: Lyophilized. Solubility: Soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences beta-Amyloid (1-40) (0.5mg). CAS: 131438-79-4
Formula: C194H295N53O58S. MW: 4329.9. Purity: ≥95%. Appearance: White to off-white powder. Solubility: Soluble in 5% acetic acid. Long Term Storage: -20°C.
Enzo Life Sciences L-Glutathione (oxidized form) (5g). CAS: 27025-41-8
Alternative name: GSSG, (gamma-Glu-Cys-Gly)2. Formula: C20H32N6O12S2. MW: 612.6. Purity: ≥95.0% (HPLC). Formulation: Free acid. Solubility: Soluble in water. Long Term Storage: +4°C.
Enzo Life Sciences Ghrelin (human) (0.5mg). CAS: 258279-04-8
Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on the cardiovascular and immune system. Formula: C149H249N47O42. MW: 3370.9. Purity: ≥98%. Formulation: Lyophilized. Solubility: Soluble in distilled water or 5% acetic acid. Long Term Storage: -20°C.
Enzo Life Sciences Melittin (natural) (5mg). CAS: 20449-79-0
Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A2 (PLA2) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic. Formula: C131H229N39O31. MW: 2846.5. Purity: ≥85% (HPLC). Appearance: White to faint tan powder. MI: 14: 5824. Solubility: Soluble in PBS (5mg/ml) or water (5mg/ml). Long Term Storage: -20°C. Handling: Very hygroscopic. Protect from light.
Enzo Life Sciences Guanylin (human) (0.1mg). CAS: 183200-12-6
Guanylyl cyclase activator. Endogenous intestinal guanylyl cyclase activator. Formula: C58H87N15O21S4. MW: 1458.7. Purity: ≥96%. Appearance: White lyophilized powder. Solubility: Soluble in water. Long Term Storage: -20°C.
Enzo Life Sciences Ghrelin (human) (1mg). CAS: 258279-04-8
Endogenous GHS-R ligand. Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on the cardiovascular and immune system. Formula: C149H249N47O42. MW: 3370.9. Purity: ≥98%. Formulation: Lyophilized. Solubility: Soluble in distilled water or 5% acetic acid.
Enzo Life Sciences Z-Asp-2,6-dichlorobenzoyloxymethylketone (50mg). CAS: 153088-73-4
Irreversible, cell permeable broad-spectrum caspase inhibitor. Caspase-3 IC50: 1,1µM Caspase-6 IC50: 4,1µM Less effective on the inhibition of caspase-1- and 8-like activities. Inhibits hypoxia-induced apoptosis in neuroblastoma cells. Alternative name: Caspase family inhibitor, Z-Asp-CH2-DCB, Z-L-Asp-a-[2,6-(dichlorobenzoyl)oxy]methane. Formula: C20H17Cl2NO7. MW: 454.3. Purity: ≥98% (TLC). Appearance: White to off-white powder. Solubility: Soluble in methanol (50mg/ml) or DMSO. Long Term Storage: -20°C. Use/Stability: Stock solutions should be divided into aliquots and stored at -20°C. Handling: Keep cool and dry.
Enzo Life Sciences Z-DEVD-pNA (1mg)
Chromogenic substrate for caspase-3 with increased cell permeability. Also substrate for caspase-1, -4 and -7. λmax of pNA is 400nm. Similar to Ac-DEVD-pNA except the N-terminus is blocked by a benzyloxycarbonyl (Z) moiety which may increase cell permeability. Alternative name: Caspase 3 substrate (chromogenic). Formula: C32H38N6O14. MW: 730.7. Purity: ≥99% (HPLC). Formulation: Lyophilized. Solubility: Soluble in DMSO or acetonitrile. Long Term Storage: -20°C.
Enzo Life Sciences Ac-IETD-pNA (1mg)
Caspase and granzyme substrate. Chromogenic substrate for caspase-6, -8 and granzyme B. Also a substrate for caspase-10. Similar to Ac-IETD-AMC and Ac-IETD-AFC but cleavage is monitored colorimetrically by absorbance at 405 nm. Alternative name: Caspase-8 substrate (chromogenic), Granzyme B substrate (chromogenic). Formula: C27H38N6O12. MW: 638.6. Purity: ≥98% (HPLC). Formulation: Lyophilized. Peptide content: 70-90%. Solubility: Soluble in DMSO. Dilute with buffer, pH 7.0-7.5. Long Term Storage: -20°C. Handling: Keep cool and dry.
Enzo Life Sciences Z-YVAD-pNA (1mg)
Chromogenic substrate for caspase-1 with increased cell permeability. λmax of pNA is 400nm. Alternative name: Caspase 1 substrate (chromogenic). Formula: C35H40N6O11. MW: 720.7. Purity: ≥97% (HPLC). Appearance: White powder. Formulation: Lyophilized. TFA salt. Solubility: Soluble in DMSO. Can be diluted with basic buffers. Long Term Storage: -20°C. Handling: Keep cool and dry.
Enzo Life Sciences Z-Phe-Tyr(tBu)-diazomethylketone (5mg)
Irreversible inhibitor of cathepsin L. Alternative name: Z-FY(tBu)-DMK. Formula: C31H34N4O5. MW: 542.6. Purity: ≥98%. Solubility: Soluble in ethyl acetate (10mg/ml) or DMSO. Long Term Storage: -20°C.
Enzo Life Sciences BEC . ammonium salt (5mg). CAS: 63107-40-4 (non-salt)
Slow-binding competitive inhibitor of arginase I (Ki=0.4-0.6µM & KD=2.22µM for recombinant rat liver arginase) and arginase II (Ki=0.31µM at pH 7.5 and 0.03µM at pH 9.5 for human recombinant type II arginase). Enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. Does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. Inhibitor of rat aortic smooth muscle cell proliferation. Alternative name: S-(2-Boronoethyl)-L-cysteine . NH4. Formula: C5H11BNO4S . NH4. MW: 192.0 . 18.0. Purity: ≥95% (TLC). Solubility: Soluble in water (10mg/ml). Long Term Storage: +4°C. Handling: Very hygroscopic. Keep under inert gas. Keep cool and dry.
Enzo Life Sciences SB 225002 (5mg). CAS: 182498-32-4
Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROα-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages. Alternative name: N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea. Purity: ≥98% (HPLC). Appearance: Yellow solid. Solubility: Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences Microcystin-HtyR (25µg)
Isolated from Microcystis aeruginosa. Microcystin containing a homotyrosine (Hty) in position 2 and arginine (R) in position 4. Hepatotoxic. Alternative name: [Hty2]microcystin-YR. Purity: ≥95% (HPLC). Appearance: White to off-white powder or oily film adhered to inside of the vial. Solubility: Soluble in methanol or DMSO. Long Term Storage: -20°C.