STEMCELL Technologies XAV939, Size: 25 mg

Supplier:  STEMCELL Technologies 1001052

Inhibit tankyrase (TNKS) 1 and 2 with XAV939 (Huang et al. Nature, 2009). By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells (Huang et al. Nature, 2009). This WNT pathway inhibitor inhibits colony formation of APC-deficient, β-catenin-dependent DLD-1 colorectal cancer cells (Huang et al.); induces cardiomyogenesis in mesoderm progenitor cells derived from mouse embryonic stem cells (Wang et al.); and, in combination with the SMAD inhibitors LDN193189 and SB431542, promotes induction of forebrain fates in human pluripotent stem cell lines (Maroof et al.). XAV939 is supplied as a crystalline solid with ≥ 98% purity; Molecular weight 312.3 g/mol; CAS number 284028-89-3. Visit STEMCELL.com for more information and related products.

Catalog No. NC2188021