Tris(hydroxymethyl)aminomethane, 99%, Thermo Scientific Chemicals

Description

Tris(hydroxymethyl)aminomethane is used as buffers in biochemistry and molecular biology laboratories. It is used as a primary standard to standardize acid solutions for chemical analysis. It finds application in cell membranes to increase its permeability. As an alternative to sodium bicarbonate, it used in the treatment of metabolic acidosis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tris(hydroxymethyl)aminomethane is used as buffers in biochemistry and molecular biology laboratories. It is used as a primary standard to standardize acid solutions for chemical analysis. It finds application in cell membranes to increase its permeability. As an alternative to sodium bicarbonate, it used in the treatment of metabolic acidosis.

Solubility
Soluble in water, ethylene glycol, methanol, ethanol,dimethyl formamide, acetone, ethyl acetate, olive oil, chloroform and alkaline solution.

Notes
Hygroscopic. Incompatible with bases and strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 77-86-1
• Molecular Formula: C4H11NO3
• Molecular Weight (g/mol): 121.136
• MDL Number: MFCD00004679
• InChI Key: LENZDBCJOHFCAS-UHFFFAOYSA-N
• Synonym: trometamol, tris, tromethamine, tris hydroxymethyl aminomethane, tham, trisamine, tris buffer, trizma, 2-amino-2-hydroxymethyl propane-1,3-diol, tris base
• PubChem CID: 6503
• ChEBI: CHEBI:9754
• IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol
• SMILES: C(C(CO)(CO)N)O

• Melting Point: 168°C to 172°C
• Density: 1.353
• Boiling Point: 219°C to 220°C (10mmHg)
• Linear Formula: (HOCH₂)₃CNH₂
• Quantity: 500 g
• Beilstein: 741883
• Sensitivity: Hygroscopic
• Merck Index: 14,9772
• Solubility Information: Soluble in water,ethylene glycol,methanol,ethanol,dimethyl formamide,acetone,ethyl acetate,olive oil,chloroform and alkaline solution.
• Formula Weight: 121.14
• Percent Purity: 99%
• Chemical Name or Material: Tris(hydroxymethyl)aminomethane

Safety and Handling

Hazard Category	Warning
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	GHS P Statement P261-P280-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapors/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
EINECSNumber	201-064-4
RTECSNumber	TY2900000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only