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  7. Trifluoroacetic acid, 99%, Thermo Scientific Chemicals

Trifluoroacetic acid, 99%, Thermo Scientific Chemicals

Catalog No. AAA1219836
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Quantity:
100 g
500 g
2500 g

Description

Solvent, catalyst, strong non-oxidizing acid

The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

Solubility
Miscible with ether, acetone, ethanol, benzene, hexane, and CCl4

Notes
Trifluoroacetic acid (TFA) is a stable, hygroscopic, volatile and low-boiling organic acid. Storage in a cool place is recommended.

Chemical Identifiers

CAS 76-05-1
Molecular Formula C2HF3O2
Molecular Weight (g/mol) 114.02
MDL Number MFCD00004169
InChI Key DTQVDTLACAAQTR-UHFFFAOYSA-N
Synonym trifluoroacetic acid, perfluoroacetic acid, trifluoroethanoic acid, trifluoroacetic acid, acetic acid, trifluoro, trifluoroaceticacid, cf3cooh, trifluoro acetic acid, trifluoro-acetic acid, kyselina trifluoroctova
PubChem CID 6422
ChEBI CHEBI:45892
IUPAC Name trifluoroacetic acid
SMILES OC(=O)C(F)(F)F

Specifications

Melting Point -15°C
Boiling Point 72°C to 73°C
Assay Percent Range 99%
Beilstein 742035
Solubility Information Miscible with ether,acetone,ethanol,benzene,hexane,and CCl4
Formula Weight 114.02
Density 1.480
Quantity 500 g
Physical Form Liquid
Refractive Index 1.284
Sensitivity Hygroscopic
Chemical Name or Material Trifluoroacetic Acid
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Safety and Handling

Hazard Category H290-H314-H332-H335
Precautionary Statement P234-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P390-P501c
DOTInformation Hazard Class: 8; Packaging Group: I
EINECSNumber 200-929-3
RTECSNumber AJ9625000
TSCA Yes
storageNote1 Hygroscopic
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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