Triethyl 2-phosphonopropionate, 98%, Thermo Scientific Chemicals

Description

Triethyl 2-phosphonopropionate is used as a reactant in intramolecular conjugate addition for the synthesis of floresolide B, enantioselective synthesis of spiroindane di-methyl acetic acid and in stereo selective intramolecular Diels-Alder reactions. It plays an important role in Horner-Wadsworth-Emmons reactions and chemoenzymatic one-pot synthesis of gamma-butyrolactones. It is also used in the preparation of 3-[2]furyl-2-methyl-acrylic acid ethyl ester by reacting with furfural.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Triethyl 2-phosphonopropionate is used as a reactant in intramolecular conjugate addition for the synthesis of floresolide B, enantioselective synthesis of spiroindane di-methyl acetic acid and in stereo selective intramolecular Diels-Alder reactions. It plays an important role in Horner-Wadsworth-Emmons reactions and chemoenzymatic one-pot synthesis of gamma-butyrolactones. It is also used in the preparation of 3-[2]furyl-2-methyl-acrylic acid ethyl ester by reacting with furfural.

Solubility
Miscible with chloroform and methanol.

Notes
Incompatible with strong bases.

Specifications

Chemical Identifiers

• CAS: 3699-66-9
• Molecular Formula: C9H19O5P
• Molecular Weight (g/mol): 238.22
• MDL Number: MFCD00009159
• InChI Key: BVSRWCMAJISCTD-UHFFFAOYSA-N
• Synonym: triethyl 2-phosphonopropionate, ethyl 2-diethoxyphosphoryl propanoate, ethyl-2-diethylphosphono propanoate, diethyl 1-carbethoxy ethylphosphonate, propanoic acid, 2-diethoxyphosphinyl-, ethyl ester, diethyl ethoxycarbonylethyl-phosphonate, diethyl 1-ethoxycarbonyl ethanephosphonate, 2-diethoxyphosphinyl propanoic acid ethyl ester, diethyl 1-ethoxycarbonyl ethanephosphonate∼2-phosphonopropionic acid triethyl ester, triethyl2-phosphonopropionate
• PubChem CID: 107155
• IUPAC Name: ethyl 2-diethoxyphosphorylpropanoate
• SMILES: CCOC(=O)C(C)P(=O)(OCC)OCC

• Density: 1.111
• Boiling Point: 143°C to 144°C (12mmHg)
• Flash Point: 88°C (190°F)
• Odor: Odorless
• Refractive Index: 1.432
• Quantity: 50 g
• Beilstein: 1786994
• Solubility Information: Miscible with chloroform and methanol.
• Formula Weight: 238.22
• Percent Purity: 98%
• Chemical Name or Material: Triethyl 2-phosphonopropionate

Safety and Handling

Hazard Category	H227-H315-H319-H335
Hazard Statement	GHS H Statement H227 Combustible liquid.
Precautionary Statement	P210-P235-P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P370+P378q-P501c
EINECSNumber	223-033-4
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only