Tolfenamic acid, 99+%, Thermo Scientific Chemicals

Description

NSAID that activates calcium-activated potassium channels

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.

Solubility
Soluble in water (slightly), acetone (∼10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (∼10 mg/ml) and ethanol (50 mg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 13710-19-5
• Molecular Formula: C14H12ClNO2
• Molecular Weight (g/mol): 261.705
• MDL Number: MFCD00133865
• InChI Key: YEZNLOUZAIOMLT-UHFFFAOYSA-N
• Synonym: tolfenamic acid, clotam, n-3-chloro-2-methylphenyl anthranilic acid, 2-3-chloro-2-methylphenyl amino benzoic acid, tolfedine, acido tolfenamico, acide tolfenamique, acidum tolfenamicum, tolfine, n-2-methyl-3-chlorophenyl anthranilic acid
• PubChem CID: 610479
• ChEBI: CHEBI:32243
• IUPAC Name: 2-(3-chloro-2-methylanilino)benzoic acid
• SMILES: CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O

• Color: White
• Quantity: 10 g
• UN Number: UN2811
• Merck Index: 14,9513
• Solubility Information: Soluble in water (slightly),acetone (∽10mg/ml),DMSO (52mg/ml at 25°C),methanol (∽10mg/ml) and ethanol (50mg/ml).
• Formula Weight: 261.7
• Percent Purity: ≥99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Tolfenamic acid

Safety and Handling

Hazard Category	H301
Hazard Statement	GHS H Statement H301 Toxic if swallowed.
Precautionary Statement	P264b-P270-P301+P310-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	237-264-3
RTECSNumber	CB2687500
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only