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Tamoxifen, 98%, Thermo Scientific Chemicals
Description
Inhibitor of protein kinase C and induces apoptosis in cancer cells. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Tamoxifen is a tertiary aminobenzene that acts by competitively binding and antagonizing estrogen receptors to reduce DNA synthesis
- When estradiol cannot bind estrogen receptors, the DNA response element is not activated
- Tamoxifen upregulates the production of TGFb and slows tumor growth
- Tamoxifen inhibits the production of IGF-1, a stimulator of tumor growth
Application
- Tamoxifen may be useful in the study of tumorigenesis, growth, and inflammation
- It is suitable for in vitro experiments
Specifications
Specifications
Color | White |
Quantity | 500 mg |
Merck Index | 14,9048 |
Solubility Information | Insoluble in water; Soluble in methanol,ethanol,propanol or propylene glycol;Soluble in dimethyl sulfoxide,dichloromethane and ethanol; Insoluble in water. |
Formula Weight | 371.52 |
Percent Purity | 98% |
Physical Form | Powder |
Chemical Name or Material | Tamoxifen |
Safety and Handling
Hazard Category | H302-H350-H360FD-H362 |
Hazard Statement | GHS H Statement H350-H360-H362 May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children. |
Precautionary Statement | P201-P202-P260-P263-P264b-P270-P281-P301+P312-P308+P313-P330-P501c |
EINECSNumber | 234-118-0 |
RTECSNumber | KR5919600 |
TSCA | No |
Recommended Storage | Store at -20°C |
RUO – Research Use Only
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