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Tocris Bioscience™ SZL P1-41

Selective Skp2 inhibitor; suppresses E3 ligase activity

Supplier: Tocris Bioscience™ 5076/50

Catalog No. 50-765-0

$1,283.00 / Each of 1

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Description

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Specifications

Purity	>98%
Product Type	SZL P1-41
Inhibitors	SZL P1-41

Quantity	50 mg
Molecular Weight (g/mol)	420.52

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Tocris Bioscience™ SZL P1-41

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