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SSR 69071, Tocris Bioscience™

Catalog No. 250610
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent, orally active human leukocyte elastase inhibitor

High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.

Chemical Identifiers

CAS 344930-95-6
Molecular Formula C27H32N4O7S
Molecular Weight (g/mol) 556.634
InChI Key DRZXDZYWZSKFDL-UHFFFAOYSA-N
Synonym d0b3mv, dsstox_cid_27368, dsstox_rid_82301, dsstox_gsid_47368, 2-6-methoxy-4-1-methylethyl-1,1-dioxido-3-oxo-1,2-benzisothiazol-2 3h-yl methoxy-9-2-1-piperidinyl ethoxy-4h-pyrido 1,2-a pyrimidin-4-one, 2-6-methoxy-1,1-dioxido-3-oxo-4-propan-2-yl-1,2-benzothiazol-2 3h-yl methoxy-9-2-piperidin-1-yl ethoxy-4h-py...
PubChem CID 9872438
IUPAC Name 6-methoxy-1,1-dioxo-2-[[4-oxo-9-(2-piperidin-1-ylethoxy)pyrido[1,2-a]pyrimidin-2-yl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one
SMILES CC(C)C1=CC(=CC2=C1C(=O)N(S2(=O)=O)COC3=CC(=O)N4C=CC=C(C4=N3)OCCN5CCCCC5)OC

Specifications

Quantity 10 mg
Formula Weight 556.63
Percent Purity >98%
Chemical Name or Material SSR 69071

Safety and Handling

Recommended Storage Store at +4°C
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