Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Phenols
  7. Aminophenols
  8. SKI II, Tocris Bioscience™

SKI II, Tocris Bioscience™

Catalog No. 209750
Click to view available options
Quantity:
10mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective non-lipid inhibitor of sphingosine kinase

Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).

Chemical Identifiers

CAS 312636-16-1
Molecular Formula C15H11ClN2OS
Molecular Weight (g/mol) 302.776
InChI Key ZFGXZJKLOFCECI-UHFFFAOYSA-N
Synonym ski ii, 4-4-4-chlorophenyl-2-thiazolyl amino phenol, skiii, sphk-i2, 4-4-4-chlorophenyl-1,3-thiazol-2-yl amino phenol, sphingosine kinase inhibitor 2, 4-4-4-chlorophenyl thiazol-2-ylamino phenol, phenol, 4-4-4-chlorophenyl-2-thiazolyl amino, 3vzd
PubChem CID 753704
IUPAC Name 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol
SMILES C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl

Specifications

Quantity 50 mg
Formula Weight 302.78
Percent Purity >98%
Chemical Name or Material SKI II

Safety and Handling

Recommended Storage Store at -20°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.