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Tocris Bioscience™ SCH 51344

Potent MTH1 inhibitor

Supplier: Tocris Bioscience™ 5280/50

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Catalog No. 52-805-0

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Description

SCH 51344 is a potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.

Specifications

Purity	>99%
Product Type	SCH 51344
Inhibitors	SCH 51344

Quantity	50 mg
Molecular Weight (g/mol)	316.35

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Tocris Bioscience™ SCH 51344

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