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  7. RepSox, Tocris Bioscience™

RepSox, Tocris Bioscience™

Catalog No. 374250
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective inhibitor of TGF-βRI

RepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.

RepSox synthesized to Ancillary Material Grade also available.

For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors .

Chemical Identifiers

CAS 446859-33-2
Molecular Formula C17H13N5
Molecular Weight (g/mol) 287.326
InChI Key LBPKYPYHDKKRFS-UHFFFAOYSA-N
Synonym repsox, alk5 inhibitor ii, alk5 inhibitor, 2-3-6-methylpyridin-2-yl-1h-pyrazol-4-yl-1,5-naphthyridine, tgf-beta ri kinase inhibitor ii, 2-3-6-methylpyridine-2-yl-1h-pyrazol-4-yl-1,5-naphthyridine, 2-3-6-methyl-2-pyridinyl-1h-pyrazol-4-yl-1,5-naphthyridine, transforming growth factor-beta type i receptor kinase inhibitor ii, 2-5-6-methylpyridin-2-yl-1h-pyrazol-4-yl-1,5-naphthyridine
PubChem CID 449054
IUPAC Name 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
SMILES CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4

Specifications

Quantity 50 mg
Formula Weight 287.32
Percent Purity >99%
Chemical Name or Material RepSox

Safety and Handling

Recommended Storage Store at +4°C
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