RAB5 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA3915

Catalog No. 01-674-578

Description

PA3-915 detects Rab5 from human and rat samples. PA3-915 has been successfully used in Western blot and immunofluorescence procedures. The PA3-915 immunogen is recombinant human Rab5.

RAB5 are among the small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.

Specifications

• Antigen: RAB5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAB5A
• Gene Alias: 2410015H04Rik; AI663973; AU021172; nnyRab5a; Rab 5; Rab 5A; RAB5; RAB5A; RAB5A, member RAS oncogene family; Ras related protein; RAS-associated protein RAB5A; ras-related protein Rab-5A; Small GTP-binding protein rab5
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry, Western Blot
• Concentration: Conc. Not Determined
• Formulation: whole serum with 0.05% sodium azide
• Gene Accession No.: M0RC99, P20339
• Gene Symbols: RAB5A
• Immunogen: Recombinant human Rab5.
• Regulatory Status: RUO
• Gene ID (Entrez): 5868, 64633
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid