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  8. (R)-(+)-Bay K 8644, Tocris Bioscience™

(R)-(+)-Bay K 8644, Tocris Bioscience™

Catalog No. 154550
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644

(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

Chemical Identifiers

CAS 98791-67-4
Molecular Formula C16H15F3N2O4
Molecular Weight (g/mol) 356.301
InChI Key ZFLWDHHVRRZMEI-CYBMUJFWSA-N
Synonym r-+-bay k 8644, bay-k-8644 r-+-, methyl 4r-2,6-dimethyl-5-nitro-4-2-trifluoromethyl phenyl-1,4-dihydropyridine-3-carboxylate, bay-k-8644 r-+, tocris-1546, bidd:pxr0106, r-bayk8644, r-bay k8644, r-bay-k-8644, r + bay k 8644
PubChem CID 6604881
IUPAC Name methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
SMILES CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC

Specifications

Quantity 50 mg
Formula Weight 356.3
Percent Purity >97%
Chemical Name or Material (R)-(+)-Bay K 8644

Safety and Handling

Recommended Storage Store at +4°C
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