Quinine hemisulfate monohydrate, 98+%, Thermo Scientific Chemicals

Description

Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Solubility
Soluble in a mixture of chloroform and absolute alcohol (2:1).

Notes
Light sensitive. Incompatible with strong oxidizing agents, alkalis, ammonia, strong bases and iodine.

Specifications

Chemical Identifiers

• CAS: 6119-70-6
• Molecular Formula: C40H54N4O10S
• Molecular Weight (g/mol): 782.95
• MDL Number: MFCD00150790
• InChI Key: ZHNFLHYOFXQIOW-OIGVVMIYNA-N
• Synonym: Quinine sulfate (2:1) (salt) dihydrate; Quinine sulfate dihydrate
• PubChem CID: 134129495
• IUPAC Name: (R)-[(2R,4R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid;tetrahydrate
• SMILES: O.O.OS(O)(=O)=O.[H][C@@]1(CN2CCC1C[C@@]2([H])[C@H](O)C1=C2C=C(OC)C=CC2=NC=C1)C=C.[H][C@@]1(CN2CCC1C[C@@]2([H])[C@H](O)C1=C2C=C(OC)C=CC2=NC=C1)C=C

• Melting Point: 217°C to 218°C (decomposition)
• Odor: Odorless
• Quantity: 250 g
• Beilstein: 6113937
• Sensitivity: Light sensitive
• Merck Index: 14,8061
• Solubility Information: Soluble in a mixture of chloroform and absolute alcohol (2:1).
• Optical Rotation: −241° (c=2 in 0.1M HCl)
• Formula Weight: 391.47 (373.46 Anhydrous)
• Percent Purity: 99%
• Chemical Name or Material: Quinine hemisulfate monohydrate

Safety and Handling

Hazard Category	H302+H312+H332-H315-H317-H319-H334-H335
Hazard Statement	GHS H Statement H301-H334-H317 Toxic if swallowed. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.
Precautionary Statement	P261-P264b-P270-P271-P272-P280-P285-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P333+P313-P362-P501c
EINECSNumber	212-359-2
RTECSNumber	VA8440000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only