Propargyl bromide, 80% in toluene, stab. with MgO, Thermo Scientific Chemicals

Description

Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

Solubility
Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.

Notes
Light sensitive. Store in a cool place. Incompatible withbases, strong oxidizing agents, copper, peroxides, silver, silver oxides, mercury and mercury oxides.

Specifications

Chemical Identifiers

• CAS: 106-96-7
• Molecular Formula: C3H3Br
• Molecular Weight (g/mol): 118.961
• MDL Number: MFCD00000241
• InChI Key: YORCIIVHUBAYBQ-UHFFFAOYSA-N
• Synonym: propargyl bromide, 3-bromopropyne, 3-bromo-1-propyne, 1-propyne, 3-bromo, 2-propynyl bromide, propynyl bromide, 1-bromo-2-propyne, propyne, 3-bromo, gamma-bromoallylene, 1-brom-2-propin
• PubChem CID: 7842
• IUPAC Name: 3-bromoprop-1-yne
• SMILES: C#CCBr

• Melting Point: -61°C
• Density: 1.335
• Boiling Point: 88°C to 90°C
• Flash Point: 3°C (37°F)
• Refractive Index: 1.494
• Quantity: 1000 mL
• UN Number: UN2924
• Beilstein: 605309
• Sensitivity: Light sensitive
• Solubility Information: Miscible with ethanol,ether,benzene,carbon tetrachloride and chloroform. Immiscible with water.
• Formula Weight: 118.97
• Concentration or Composition (by Analyte or Components): 80% in toluene
• Chemical Name or Material: Propargyl bromide, stabilized with MgO

Safety and Handling

Hazard Category	H225-H301-H304-H314-H335-H336-H361-H373
Hazard Statement	GHS H Statement H225-H300-H304-H361-H373-H314-H335-H336 Highly flammable liquid and vapour. Fatal if swallowed. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Causes severe skin burns and eye damage. May cause respiratory irritation. May cause drowsiness or dizziness.
Precautionary Statement	P201-P202-P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P281-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: II; Proper Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
EINECSNumber	203-447-1
RTECSNumber	UK4375000
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only