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Thermo Scientific™ ProPac™ WCX-10 HPLC Columns

Separate proteins and their variants using these weak cation-exchange columns with exceptionally high resolution.

Supplier:  Thermo Scientific™ 063474

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Catalog No. DX063474


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Description

Description

Use Thermo Scientific™ ProPac™ WCX-10 LC Columns to provide exceptionally high resolution for separations of proteins and their variants. Based on stationary phases composed of 10μm nonporous polymeric beads, ProPac columns resolve isoforms that differ by a single charged residue. A thin, hydrophilic layer grafted to the particle core eliminates unwanted secondary interactions. The cation-exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity.

Multiple Formats for Greater Flexibility
  • ProPac WCX-10 column is a weak cation-exchanger with a carboxylate functional group
  • Column sizes range from 2mm I.D., for analytical work, up to 22mm I.D. for semi-prep work
Superior Performance for Protein Analysis
  • Ideal for characterization and quality control assessment of MAbs and other proteins
  • Well-suited for characterization of related protein variants including deamidation and MAb lysine truncation variants
  • Unequaled high-resolution separations
  • Unmatched column-to-column and lot-to-lot reproducibility eliminates column variability as a concern in stability and QA/QC testing
Specifications

Specifications

Semi-Preparative Column
5 mL/min
3000 psi (207 bar)
10 μm
Nonporous
N/A
ProPac
Ion Exchange
Bio-LC
9 mm
250 mm
pH 2 to 12, 80% compatible with acetonitrile and acetone, compatible with nonionic and zwitterionic detergents, incompatible with cationic detergents
2 to 12
60°C
Carboxylate
Spherical, Nonporous Polymer
Ion Exchange
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