Phenylethyl 3,4-dihydroxycinnamate, 98+%, Thermo Scientific Chemicals

Description

Inhibitor of protein tyrosine kinase, and is cytotoxic to cancer cell lines

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Solubility
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.

Notes
Light sensitive. Incompatible with oxidizing agents and heat.

Specifications

Chemical Identifiers

• CAS: 104594-70-9
• Molecular Formula: C17H16O4
• Molecular Weight (g/mol): 284.31
• MDL Number: MFCD00866470
• InChI Key: SWUARLUWKZWEBQ-VQHVLOKHSA-N
• Synonym: caffeic acid phenethyl ester, phenethyl caffeate, cape, capeee, phenethyl 3-3,4-dihydroxyphenyl acrylate, phenylethyl caffeate, unii-g960r9s5sk, caffeic acid phenylethyl ester, 2-phenylethyl caffeate, caffeic acid 2-phenylethyl ester
• PubChem CID: 5281787
• ChEBI: CHEBI:8062
• IUPAC Name: 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• SMILES: OC1=CC=C(\C=C\C(=O)OCCC2=CC=CC=C2)C=C1O

• Melting Point: 127°C to 129°C
• Color: White to Yellow
• Quantity: 250 mg
• Sensitivity: Light sensitive
• Solubility Information: Soluble in ethyl acetate at 50mg/ml; Soluble in DMSO and ethanol.
• Formula Weight: 284.31
• Percent Purity: ≥99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Phenylethyl 3,4-dihydroxycinnamate

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
RTECSNumber	UD3334375
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only