PF 04449613, >98%, Tocris Bioscience™

Description

Potent PDE9 inhibitor; brain penetrant

PF 04449613 is a potent PDE9 inhibitor (IC50 = 22 nM). Also exhibits a high affinity for cGMP (Km ∼170 nM). PF 04449613 reduces body fat in mice with diet-induced obesity, stimulating mitochondrial activity in brown and white fat, and improving cardiometabolic syndrome symptoms. Brain penetrant.

Specifications

Chemical Identifiers

• CAS: 1236858-52-8
• Molecular Formula: C21H25N5O3
• Molecular Weight (g/mol): 395.463
• InChI Key: WEDCMPMDOVEMSV-CQSZACIVSA-N
• Synonym: d04jpg, pde 9 inhibitor alzheimer's disease, pde 9 inhibitor alzheimer's disease , pfizer, phosphodiesterase 9 inhibitor alzheimer's disease , pfizer, 1,5-dihydro-6-1r-1-3-phenoxy-1-azetidinyl ethyl-1-tetrahydro-2h-pyran-4-yl-4h-pyrazolo 3,4-d pyrimidin-4-one
• PubChem CID: 46851937
• IUPAC Name: 1-(oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-2H-pyrazolo[3,4-d]pyrimidin-4-one
• SMILES: CC(C1=NC(=O)C2=CNN(C2=N1)C3CCOCC3)N4CC(C4)OC5=CC=CC=C5

• Linear Formula: C₂₁H₂₅N₅O₃
• Quantity: 10mg
• Solubility Information: Soluble to 100mM in DMSO and to 10mM in 1eq. HCl with gentle warming
• Formula Weight: 395.45
• Chemical Name or Material: 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]
• Grade: >98%

Safety and Handling

Recommended Storage

Store at −20°C