Gibco™ PeproGMP® Human Heregulin beta-1 Recombinant Protein, PeproTech®

Recombinant Protein

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Accession Number

Q02297

For Use With (Application)

Functional Assay

Format

Lyophilized

Formulation

Protein with no preservative

Molecular Weight (g/mol)

7.5

Name

HRG beta-1

Quantity

100 μg

Immunogen

Human Heregulin beta-1

Storage Requirements

-20°C or -80°C if preferred

Regulatory Status

RUO

Endotoxin Concentration

<0.1

Assays

Functional Assay

Conjugate

Unconjugated

Recombinant

Recombinant

Activity

Determined by proliferation of human MCF-7 cells.

Expression System

E. coli

Product Line

PeproGMP

Purity or Quality Grade

Purified