Paclitaxel, 99.5+%, Thermo Scientific Chemicals

Description

Paclitaxel (CAS # 33069-62-4) is a microtubule inhibitor produced from the extract of the Pacific yew tree.

Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi's sarcoma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Paclitaxel is a tetracyclic diterpenoid isolated from the Pacific yew, Taxus brevifolia
• Paclitaxel acts as an antineoplastic agent by binding tubulin and preventing cell division
• Paclitaxel may also bind Bcl-2 and lead to disinhibition of apoptosis

Application

• Paclitaxel is used in the study of lung, breast, and ovarian cancers; it may be useful in the research of other cancer types
• It is suitable for cell culture, biochemistry, and molecular biology applications

Specifications

Chemical Identifiers

• CAS: 33069-62-4
• Molecular Formula: C47H51NO14
• Molecular Weight (g/mol): 853.92
• MDL Number: MFCD00869953
• InChI Key: RCINICONZNJXQF-VAZQATRQSA-N
• Synonym: paclitaxel, taxol, taxol a, abraxane, paxene, paxceed, plaxicel, yewtaxan, onxol, ebetaxel
• PubChem CID: 133640187
• IUPAC Name: (1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
• SMILES: CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1

• Melting Point: 213°C (decomposition)
• Color: White
• Quantity: 500 mg
• Beilstein: 1420457
• Merck Index: 14,6982
• Solubility Information: Soluble in DMSO (200mg/ml) or ethanol (40mg/ml); Soluble in dimethylsulfoxide,methanol,ethanol,acetonitrile,cremophor and dimehtylsulfamide; Sparingly soluble in aqueous buffer.
• Formula Weight: 853.91
• Percent Purity: ≥99.5%
• Physical Form: Crystalline Solid
• Chemical Name or Material: Paclitaxel

Safety and Handling

Hazard Category	H302+H312+H332-H318-H334-H335-H361
Hazard Statement	GHS H Statement H334-H341-H361-H318-H302-H312-H332-H335-H315-H317 May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child. Causes serious eye damage. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. May cause respiratory irritation. Causes skin irritation. May cause an allergic skin reaction.
Precautionary Statement	P201-P202-P261-P264b-P270-P271-P281-P285-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P310-P312-P330-P342+P311-P363-P501c
RTECSNumber	DA8340700
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only