Nimesulide, Thermo Scientific Chemicals

Description

Highly selective cyclooxygenase-2 inhibitor which induces apoptosis

Nimesulide are used for the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea, . Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. It was effective in reducing pain associated with osteoarthritis, cancer, thrombophlebitis, oral surgery in adults, otorhinolaryngological diseases and traumatic injury. Nimesulide is demonstrated to suppress azoxymethane-induced carcinogenesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 51803-78-2
• Molecular Formula: C13H12N2O5S
• Molecular Weight (g/mol): 308.308
• MDL Number: MFCD00079470
• InChI Key: HYWYRSMBCFDLJT-UHFFFAOYSA-N
• Synonym: nimesulide, mesulid, n-4-nitro-2-phenoxyphenyl methanesulfonamide, flogovital, sulidene, nimed, 4-nitro-2-phenoxymethanesulfonanilide, nisulid, nimesulidum inn-latin, nimesulida inn-spanish
• PubChem CID: 4495
• ChEBI: CHEBI:44445
• IUPAC Name: N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
• SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2

• Melting Point: 145°C to 147°C
• Color: Yellow
• Quantity: 25 g
• UN Number: UN2811
• Merck Index: 14,6548
• Solubility Information: Soluble in water (<50 μg/ml),1:10 DMSO:PBS (pH 7.2) (<200 μg/ml),ethanol (1mg/ml),DMSO (15mg/ml),DMF (15mg/ml),chloroform,dichloromethane,acetone (freely soluble),and 1N NaOH.
• Formula Weight: 308.31
• Physical Form: Needle-like Crystals
• Chemical Name or Material: Nimesulide

Safety and Handling

Hazard Category	H301
Hazard Statement	GHS H Statement H301 Toxic if swallowed.
Precautionary Statement	P264b-P270-P301+P310-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	257-431-4
RTECSNumber	PB0970000
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only