NF1 Monoclonal Antibody (McNFn27a), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA1084

Catalog No. 01-670-103

Description

MA1-084 detects neurofibromin in human, rat and mouse cells. MA1-084 has been successfully used in Western blot, procedures. By Western blot, this antibody detects a ∽230-260 kDa protein. The MA1-084 immunogen is a synthetic peptide corresponding to the N-terminal residues 27-41 of human neurofibromin.

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

Specifications

• Antigen: NF1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P21359, P97526, Q04690
• Gene Symbols: NF1
• Immunogen: Synthetic peptide corresponding to the N-terminal residues 27-41 of human neurofibromin.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Affinity Purification, ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
• Clone: McNFn27a
• Conjugate: Unconjugated
• Gene: NF1
• Gene Alias: AW494271; DKFZp686J1293; E030030H24Rik; FLJ21220; neurofibromatosis 1; Neurofibromatosis type 1; neurofibromatosis-related protein NF-1; Neurofibromin; neurofibromin 1; Neurofibromin truncated; NF1; Nf-1; NFNS; VRNF; WSS
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 18015, 24592, 4763
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid