Naloxone hydrochloride, 98%, Thermo Scientific Chemicals

Description

Naloxone hydrochloride, CAS # 357-08-4, is involved in the blockade of the mu-opioid receptor and removal of other compounds from the receptor site.

A specific opiate antagonist. Blocks the action of sigma-agonists at opioid sites.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Naloxone hydrochloride the hydrochloride salt of the anti-opioid naloxone

Application

• Naloxone is a fast-acting inverse agonist of the mu-opioid receptor that can be used to competitively inhibit the binding of opioid compounds

Specifications

Chemical Identifiers

• CAS: 357-08-4
• Molecular Formula: C19H22ClNO4
• Molecular Weight (g/mol): 363.838
• MDL Number: MFCD00069322
• InChI Key: RGPDIGOSVORSAK-STHHAXOLSA-N
• Synonym: naloxone hydrochloride, naloxone hcl, narcan, evzio, unii-f850569pqr, nalonee, 17-allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride, narcan tn, naloxonehydrochloride
• PubChem CID: 5464092
• IUPAC Name: (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
• SMILES: C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl

• Melting Point: 200°C to 205°C
• Color: White
• Quantity: 500 mg
• Merck Index: 14,6362
• Solubility Information: Soluble in water (73mg/ml),ethanol (3.3mg/ml),methanol (50mg/ml) and dimethyl sulfoxide (73mg/ml). Insoluble in ether
• Formula Weight: 363.84
• Percent Purity: 98%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Naloxone hydrochloride

Safety and Handling

Hazard Category	H302-H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber	206-611-0
RTECSNumber	QD2275000
TSCA	No
storageNote1	2° to 8°C
Recommended Storage	Keep cold

SDS

RUO – Research Use Only