N,O-Dimethylhydroxylamine hydrochloride, 98%, Thermo Scientific Chemicals

Description

N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides.

Solubility
Soluble in water, dimethyl sulfoxide and methanol.

Notes
Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 6638-79-5
• Molecular Formula: C2H8ClNO
• Molecular Weight (g/mol): 97.54
• MDL Number: MFCD00012485
• InChI Key: USZLCYNVCCDPLQ-UHFFFAOYSA-N
• Synonym: n,o-dimethylhydroxylamine hydrochloride, n,o-dimethylhydroxylamine hcl, n-methoxymethylamine hydrochloride, methanamine, n-methoxy-, hydrochloride, o,n-dimethylhydroxylamine hydrochloride, n-methoxymethanamine hydrochloride, o,n-dimethyl-hydroxylamine hydrochloride, methoxy methyl amine hydrochloride, n,o-dimethylhydroxyamine hydrochloride, n,o-dimethylhydroxylaminehydrochloride
• PubChem CID: 81138
• SMILES: [H+].[Cl-].CNOC

• Melting Point: 112°C to 115°C
• Quantity: 100 g
• Beilstein: 3650353
• Sensitivity: Hygroscopic
• Solubility Information: Soluble in water,dimethyl sulfoxide and methanol.
• IUPAC Name: N-methoxymethanamine;hydrochloride
• Formula Weight: 97.55
• Percent Purity: 98%
• Chemical Name or Material: N,O-Dimethylhydroxylamine hydrochloride

Safety and Handling

Hazard Category	H315-H319
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362
EINECSNumber	229-642-1
TSCA	Yes
Recommended Storage	Ambient temperatures; Store under Nitrogen

SDS

RUO – Research Use Only