N,O-Bis(trimethylsilyl)acetamide, 95%, Thermo Scientific Chemicals

Description

N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further, it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this, it is used in the protection of hydroxyl groups in natural products, functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further, it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this, it is used in the protection of hydroxyl groups in natural products, functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

Solubility
Miscible with many nonpolar and polar aprotic solvents.

Notes
Air and moisture sensitive. Incompatible with strong oxidizing agents, water and acids.

Specifications

Chemical Identifiers

• CAS: 10416-59-8
• Molecular Formula: C8H21NOSi2
• Molecular Weight (g/mol): 203.43
• MDL Number: MFCD00008270
• InChI Key: SIOVKLKJSOKLIF-UHFFFAOYSA-N
• Synonym: n,o-bis trimethylsilyl acetamide, trimethylsilyl 1z-n-trimethylsilylethanimidate
• PubChem CID: 6913588
• SMILES: CC(O[Si](C)(C)C)=N[Si](C)(C)C

• Boiling Point: 71°C to 73°C (35mmHg)
• Melting Point: -24°C
• Quantity: 100 g
• UN Number: UN2920
• Beilstein: 1306669
• Flash Point: 42°C (107°F)
• Solubility Information: Miscible with many nonpolar and polar aprotic solvents.
• IUPAC Name: trimethylsilyl (1E)-N-trimethylsilylethanimidate
• Formula Weight: 203.43
• Percent Purity: 95%
• Refractive Index: 1.417
• Sensitivity: Moisture sensitive
• Density: 0.829
• Chemical Name or Material: N,O-Bis(trimethylsilyl)acetamide

Safety and Handling

Hazard Category	H226-H302-H314-H335
Hazard Statement	GHS H Statement H301-H314-H318-H226 Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapor.
Precautionary Statement	P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE LIQUIDS, FLAMMABLE, N.O.S.
EINECSNumber	233-892-7
RTECSNumber	AK3000000
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only