N-Hydroxysuccinimide, 98+%, Thermo Scientific Chemicals

Description

N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

Solubility
Soluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.

Notes
Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides and strong bases. Store in a cool place.

Specifications

Chemical Identifiers

• CAS: 6066-82-6
• Molecular Formula: C4H5NO3
• Molecular Weight (g/mol): 115.088
• MDL Number: MFCD00005516
• InChI Key: NQTADLQHYWFPDB-UHFFFAOYSA-N
• Synonym: n-hydroxysuccinimide, hosu, 1-hydroxysuccinimide, 2,5-pyrrolidinedione, 1-hydroxy, 1-hydroxy-2,5-pyrrolidinedione, succinimide, n-hydroxy, n-hydroxysuccinimde, n-hydroxysuccinimid, unii-mje3791m4t, ccris 2604
• PubChem CID: 80170
• IUPAC Name: 1-hydroxypyrrolidine-2,5-dione
• SMILES: C1CC(=O)N(C1=O)O

• Melting Point: 94°C to 99°C
• Assay Percent Range: >98%
• Quantity: 500 g
• Beilstein: 113913
• Sensitivity: Hygroscopic
• Solubility Information: Soluble in water,dimethyl formamide,alcohols and ethyl acetate. Insoluble in cold ether.
• Formula Weight: 115.09
• Percent Purity: ≥98%
• Chemical Name or Material: N-Hydroxysuccinimide

Safety and Handling

Hazard Category	H315-H319-H335
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	228-001-3
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only