Thermo Scientific™ MSTFA and MSTFA + 1% TMCS Silylation Reagent

Catalog Number	Mfr. No.	Standard Components	Quantity
PI48911	Thermo Scientific™ TS48911	MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide)	10 g
03-170-450	Thermo Scientific™ TS48929	MTBSTFA	100 mL
PI48910	Thermo Scientific™ TS48910	MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide)	10 x 1 mL ampules
PI48914	Thermo Scientific™ TS48914	MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide)	100 mL
PI48915	Thermo Scientific™ TS48915	MSTFA plus 1% TMCS (2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)-acetamide, Chlorotrimethylsilane)	10 x 1 mL ampules
PI48913	Thermo Scientific™ TS48913	MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide)	25 mL

Description

Use Thermo Scientific™ MSTFA and MSTFA + 1% TMCS Silylation Reagent for GC analyses of early eluting compounds that would otherwise be obscured in the chromatogram. MSTFA, the most volatile TMS-amide available, and its byproduct N-methyltrifluoroacetamide typically elute with the solvent front, allowing TMS derivatives of small molecules to be analyzed. Addition of Thermo Scientific™ TMCS aids derivatization of amides, secondary amines, and hindered hydroxyls not derivatized by MSTFA alone.

• Trimethylsilyl donor strength comparable to BSA and BSTFA
• Reacts to replace labile hydrogens on a wide range of polar compounds with a Si(CH₃)₃ group
• Used to prepare volatile and thermally stable derivatives for GC and MS
• Volatile byproduct, N-methyltrifluoroacetamide, has an even lower retention time than MSTFA
• Often TMS derivatives of small molecules can be analyzed when derivatized with MSTFA because the byproducts and the reagent itself usually elute with the solvent front
• Addition of Thermo Scientfic TMCS aids derivatization of amides, secondary amines and hindered hydroxyls not derivatized by MSTFA alone

Specifications

• For Use With: GC/MS
• Hazards: Flammable, Irritant

For Research Use Only. Not for use in diagnostic procedures.